Eif2ak2 - eukaryotic translation initiation factor 2-alpha kinase 2 Gene

Mus musculus

Also known as Pkr; Tik; Prkr; 2310047A08Rik; 4732414G15Rik

Gene ID: 19106 | Gene type: protein coding

About Eif2ak2

Summary

Enables double-stranded RNA binding activity and protein kinase activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of intracellular signal transduction; and regulation of hematopoietic stem cell differentiation. Acts upstream of or within cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of apoptotic process. Predicted to be located in nucleus and perinuclear region of cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak2 Products(1)

mRNA	Protein	Name
NM_011163.4	NP_035293.1	interferon-induced, double-stranded RNA-activated protein kinase

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21703541	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7519779	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	7519779	MGI
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	21123651	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	15542627	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	15542627	MGI
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	20038207	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	20038207	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	20038207	MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	20038207	MGI
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	20038207	MGI
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	7519779	MGI
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	22801494	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	7519779	MGI
involved in regulation of NLRP3 inflammasome complex assembly	IMP IMP: Inferred from mutant phenotype	22801494	MGI
involved in regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	23403623	MGI
involved in regulation of hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	23403623	MGI
involved in regulation of hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	23403623	MGI
acts upstream of or within translation	IDA IDA: Inferred from direct assay	7519779	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon-induced, double-stranded RNA-activated protein kinase

IFN- type I-induced and dsRNA-activated kinase	IFN-induced and double-stranded RNA-activated kinase
P1/eIF-2A protein kinase	T-cell viral integration site
dsRNA-activated kinase	eIF-2 alpha
eIF-2A protein kinase 2	interferon-inducible RNA-dependent

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04243	EIF2AK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18207	Eif2ak2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24684	Eif2ak2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2ak2	NCBI	NCBI:5610

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