Prkg1 - protein kinase, cGMP-dependent, type I Gene

Mus musculus

Also known as CGKI; Prkg1b; Gm19690; Prkgr1b

Gene ID: 19091 | Gene type: protein coding

About Prkg1

Summary

Enables cGMP binding activity and cGMP-dependent protein kinase activity. Involved in protein phosphorylation and signal transduction. Acts upstream of or within cGMP-mediated signaling; nervous system development; and relaxation of vascular associated smooth muscle. Located in Golgi apparatus and plasma membrane. Is expressed in several structures, including bone; central nervous system; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Apr 2022]

Prkg1 Products(3)

mRNA	Protein	Name
NM_001013833.3	NP_001013855.1	cGMP-dependent protein kinase 1 isoform alpha
NM_001411181.1	NP_001398110.1	cGMP-dependent protein kinase 1 isoform alpha
NM_011160.3	NP_035290.1	cGMP-dependent protein kinase 1 isoform beta

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cGMP binding	IDA IDA: Inferred from direct assay	10671526	MGI
enables cGMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	10671526	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10671526	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	10671526	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	15483626	MGI
involved in collateral sprouting	IMP IMP: Inferred from mutant phenotype	17954614	MGI
acts upstream of or within dendrite development	IMP IMP: Inferred from mutant phenotype	16154207	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	16154207	MGI
acts upstream of or within negative regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	15483626	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	16154207	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10671526	MGI
acts upstream of or within relaxation of vascular associated smooth muscle	IMP IMP: Inferred from mutant phenotype	15483626	MGI
involved in signal transduction	IDA IDA: Inferred from direct assay	10671526	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10671526	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16990611	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	19127022	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cGMP-dependent protein kinase 1

cGK 1	cGK1
cGMP-dependent protein kinase I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11154	PRKG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20087	Prkg1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26590	Prkg1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkg1	NCBI	NCBI:5592

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