2. Gene
  3. Pola1 - polymerase (DNA directed), alpha 1 Gene

Pola1 - polymerase (DNA directed), alpha 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pola

Gene ID: 18968 | Gene type: protein coding

About Pola1

Summary

Enables DNA-directed DNA Polymerase activity. Involved in DNA replication, synthesis of RNA primer. Acts upstream of or within DNA replication. Located in nucleus. Part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA Polymerase alpha 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Pola1 Products(1)

mRNA Protein Name
NM_008892.2 NP_032918.1 DNA polymerase alpha catalytic subunit
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
8106564 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9584195 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA replication IDA
IDA: Inferred from direct assay
8106564 MGI
acts upstream of or within DNA replication IMP
IMP: Inferred from mutant phenotype
8125989 MGI
involved in DNA replication initiation IDA
IDA: Inferred from direct assay
10523676 MGI
involved in DNA replication, synthesis of primer IDA
IDA: Inferred from direct assay
8026492 MGI
Cellular Component GO Annotation Evidence Reference Source
part of alpha DNA polymerase:primase complex IDA
IDA: Inferred from direct assay
8026492 MGI
part of alpha DNA polymerase:primase complex IPI
IPI: Inferred from physical interaction
10523676 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9584195 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase alpha catalytic subunit

DNA polymerase alpha 1, 180 kDa

DNA polymerase alpha catalytic subunit p180

G7a/Bat6Hom

polymerase, alpha 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147812 POLA1 inhibitor 1 Inhibitor 98.00% Unkown
HY-143412 MIR002 ≥99.0% Unkown
HY-143411 GEM144 / Unkown
HY-RS10816 POLA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17305 Pola1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23760 Pola1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pola1 NCBI NCBI:5422