2. Gene
  3. Plp1 - proteolipid protein (myelin) 1 Gene

Plp1 - proteolipid protein (myelin) 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as jp; Plp; msd; rsh; DM20; jimpy

Gene ID: 18823 | Gene type: protein coding

About Plp1

Summary

Predicted to enable identical protein binding activity. Predicted to be a structural constituent of myelin sheath. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including cell maturation; long-chain fatty acid biosynthetic process; and neurogenesis. Located in myelin sheath. Is expressed in several structures, including alimentary system; cardiovascular system; musculature; nervous system; and sensory organ. Used to study Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Plp1 Products(6)

mRNA Protein Name
NM_001290561.2 NP_001277490.1 myelin proteolipid protein isoform 2
NM_001359117.1 NP_001346046.1 myelin proteolipid protein isoform 1
NM_001359118.1 NP_001346047.1 myelin proteolipid protein isoform 2
NM_001359119.1 NP_001346048.1 myelin proteolipid protein isoform 1
NM_001359120.1 NP_001346049.1 myelin proteolipid protein isoform 1
NM_011123.4 NP_035253.1 myelin proteolipid protein isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15284227 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within astrocyte development IGI
IGI: Inferred from genetic interaction
24038504 MGI
acts upstream of or within axon development IGI
IGI: Inferred from genetic interaction
24038504 MGI
acts upstream of or within axon ensheathment IMP
IMP: Inferred from mutant phenotype
14169723 MGI
acts upstream of or within central nervous system myelination IMP
IMP: Inferred from mutant phenotype
1694232 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
24038504 MGI
acts upstream of or within long-chain fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
1150661 MGI
acts upstream of or within myelination IGI
IGI: Inferred from genetic interaction
24038504 MGI
acts upstream of or within myelination IMP
IMP: Inferred from mutant phenotype
1150661 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
1373175 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17634366 MGI
Cellular Component GO Annotation Evidence Reference Source
located in myelin sheath IDA
IDA: Inferred from direct assay
1694232 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myelin proteolipid protein

lipophilin

myelin synthesis deficiency

rump shaker

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10731 PLP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18783 Plp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25272 Plp1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plp1 NCBI NCBI:5354