2. Gene
  3. Pklr - pyruvate kinase liver and red blood cell Gene

Pklr - pyruvate kinase liver and red blood cell Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pk1; Pk-1; R-PK

Gene ID: 18770 | Gene type: protein coding

About Pklr

Summary

Enables Pyruvate Kinase activity. Acts upstream of or within response to Other organism. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study malaria and Pyruvate Kinase deficiency of red cells. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; Pyruvate Kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (Pyruvate Kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]

Pklr Products(2)

mRNA Protein Name
NM_001099779.1 NP_001093249.1 pyruvate kinase PKLR isoform 2
NM_013631.2 NP_038659.2 pyruvate kinase PKLR isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables pyruvate kinase activity IDA
IDA: Inferred from direct assay
7295297 MGI
Biological Process GO Annotation Evidence Reference Source
involved in glycolytic process IDA
IDA: Inferred from direct assay
7295297 MGI
acts upstream of or within response to other organism IMP
IMP: Inferred from mutant phenotype
14595440 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18698006 MGI
is active in cytosol IDA
IDA: Inferred from direct assay
30150719 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18698006 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyruvate kinase PKLR

L-PK

pyruvate kinase isozymes L/R

pyruvate kinase isozymes R/L

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12689 Mitapivat Activator 99.84% Yes
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12689A Mitapivat hemisulfate sesquihydrate Activator / Phase 4
HY-12689B Mitapivat hemisulfate Activator / Phase 4
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122682 SBI-993 98.67% Unkown
HY-135884 Tebapivat Activator 99.66% Unkown
HY-RS10601 PKLR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18255 Pklr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24735 Pklr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pklr NCBI NCBI:5313
Rattus norvegicus Pklr NCBI NCBI:24651