Pik3r1 - phosphoinositide-3-kinase regulatory subunit 1 Gene

Mus musculus

Also known as PI3K; p50alpha; p55alpha; p85alpha

Gene ID: 18708 | Gene type: protein coding

About Pik3r1

Summary

Enables Insulin Receptor substrate binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of stress fiber assembly; positive regulation of cellular component organization; and positive regulation of protein import into nucleus. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of osteoclast differentiation; and positive regulation of tumor necrosis factor production. Located in several cellular components, including cell-cell junction; cis-Golgi network; and perinuclear endoplasmic reticulum membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Used to study X-linked agammaglobulinemia. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; astroblastoma; endometrial Cancer (multiple); immunodeficiency 36; and type 2 diabetes mellitus. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Pik3r1 Products(2)

mRNA	Protein	Name
NM_001024955.2	NP_001020126.1	phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1
NM_001077495.2	NP_001070963.1	phosphatidylinositol 3-kinase regulatory subunit alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-phosphatidylinositol-3-kinase regulator activity	IDA IDA: Inferred from direct assay	7534300	MGI
enables 1-phosphatidylinositol-3-kinase regulator activity	IMP IMP: Inferred from mutant phenotype	11784871	MGI
enables insulin receptor substrate binding	IPI IPI: Inferred from physical interaction	16043515	MGI
enables kinase activator activity	IDA IDA: Inferred from direct assay	7534300	MGI
enables kinase activator activity	IMP IMP: Inferred from mutant phenotype	11784871	MGI
enables phosphatidylinositol 3-kinase regulatory subunit binding	IPI IPI: Inferred from physical interaction	20348926	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10644978	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	20348926	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	9988280	MGI
acts upstream of or within cellular response to UV	IGI IGI: Inferred from genetic interaction	17242187	MGI
acts upstream of or within cellular response to UV	IMP IMP: Inferred from mutant phenotype	17242187	MGI
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	20348926	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IGI IGI: Inferred from genetic interaction	15039234	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	15039234	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	7534300	MGI
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20348926	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	33567274	MGI
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11784871	MGI
involved in intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	20348926	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: Inferred from genetic interaction	17242187	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of myeloid leukocyte migration	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15192701	MGI
acts upstream of or within negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	25217619	MGI
acts upstream of or within negative regulation of cell-matrix adhesion	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
involved in negative regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	11038173	MGI
acts upstream of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	11038173	MGI
involved in positive regulation of focal adhesion disassembly	IDA IDA: Inferred from direct assay	11038173	MGI
involved in positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	11038173	MGI
acts upstream of or within positive regulation of leukocyte migration	IGI IGI: Inferred from genetic interaction	17053831	MGI
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	20348926	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20348926	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of or within protein import into nucleus	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	15192701	MGI
acts upstream of or within regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	25217619	MGI
acts upstream of or within regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	25217619	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	20348926	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17242187	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	17242187	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in cis-Golgi network	IDA IDA: Inferred from direct assay	25217619	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16043515	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16043515	MGI
located in membrane	IDA IDA: Inferred from direct assay	16043515	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20348926	MGI
located in perinuclear endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	25217619	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11038173	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylinositol 3-kinase regulatory subunit alpha

PI3-kinase subunit p85-alpha	PI3K regulatory subunit alpha
phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161366	OMS14	Inhibitor	99.09%	Unkown
HY-RS10536	PIK3R1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18872	Pik3r1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25363	Pik3r1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pik3r1	NCBI	NCBI:5295

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