Pfn2 - profilin 2 Gene

Mus musculus

Also known as Pfn

Gene ID: 18645 | Gene type: protein coding

About Pfn2

Summary

Predicted to enable ATP hydrolysis activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including modification of postsynaptic actin cytoskeleton; negative regulation of ruffle assembly; and positive regulation of stress fiber assembly. Acts upstream of or within negative regulation of actin filament polymerization and positive regulation of actin filament polymerization. Located in glutamatergic synapse; postsynapse; and terminal bouton. Is active in Schaffer collateral - CA1 synapse and presynapse. Is expressed in several structures, including central nervous system; cornea stroma; ganglia; hemolymphoid system gland; and tooth. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Pfn2 Products(1)

mRNA	Protein	Name
NM_019410.3	NP_062283.1	profilin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11826110	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in modification of postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	26951674	MGI
involved in modification of postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	26951674	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26951674	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26951674	MGI
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	23153535	MGI
involved in negative regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	23153535	MGI
acts upstream of or within positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	17541406	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23153535	MGI
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	23153535	MGI
involved in presynaptic actin cytoskeleton organization	EXP EXP: Inferred from Experiment	21976510	MGI
involved in presynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21976510	MGI
involved in presynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21976510	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17541406	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17541406	MGI
acts upstream of or within regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	17541406	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	17541406	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17541406	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17541406	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	17541406	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	17541406	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

profilin-2

profilin II

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10369	PFN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19627	Pfn2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26123	Pfn2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pfn2	NCBI	NCBI:5217

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