2. Gene
  3. Pfn1 - profilin 1 Gene

Pfn1 - profilin 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pfn

Gene ID: 18643 | Gene type: protein coding

About Pfn1

Summary

Enables small GTPase binding activity. Involved in modification of postsynaptic actin Cytoskeleton and synapse maturation. Acts upstream of or within neural tube closure and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; heart; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Pfn1 Products(1)

mRNA Protein Name
NM_011072.4 NP_035202.1 profilin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11826110 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
10445846 MGI
Biological Process GO Annotation Evidence Reference Source
involved in modification of postsynaptic actin cytoskeleton IDA
IDA: Inferred from direct assay
26951674 MGI
involved in modification of postsynaptic actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
26951674 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26951674 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26951674 MGI
acts upstream of or within neural tube closure IGI
IGI: Inferred from genetic interaction
10069337 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15615774 MGI
involved in synapse maturation IDA
IDA: Inferred from direct assay
26951674 MGI
involved in synapse maturation IMP
IMP: Inferred from mutant phenotype
26951674 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11274401 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26951674 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
26951674 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15615774 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

profilin-1

actin binding protein

profilin I

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136808 Pfn1-IN-1 99.17% Unkown
HY-116903 Pfn1-IN-2 / Unkown
HY-RS10368 PFN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22276 Pfn1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfn1 NCBI NCBI:5216