2. Gene
  3. Pfkm - phosphofructokinase, muscle Gene

Pfkm - phosphofructokinase, muscle Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pfk4; Pfka; Pfkx; PFK-A; PFK-M; Pfk-4; ATP-PFK

Gene ID: 18642 | Gene type: protein coding

About Pfkm

Summary

Enables 6-phosphofructokinase activity and identical protein binding activity. Acts upstream of or within several processes, including glycogen catabolic process; glycolytic process through glucose-6-phosphate; and positive regulation of Insulin secretion. Located in cytosol and sperm principal piece. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and musculoskeletal system. Used to study glycogen storage disease VII. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle). [provided by Alliance of Genome Resources, Apr 2022]

Pfkm Products(4)

mRNA Protein Name
NM_001163487.1 NP_001156959.1 ATP-dependent 6-phosphofructokinase, muscle type
NM_001163488.1 NP_001156960.1 ATP-dependent 6-phosphofructokinase, muscle type
NM_001357688.1 NP_001344617.1 ATP-dependent 6-phosphofructokinase, muscle type
NM_021514.4 NP_067489.3 ATP-dependent 6-phosphofructokinase, muscle type
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 6-phosphofructokinase activity IDA
IDA: Inferred from direct assay
2521854 MGI
enables 6-phosphofructokinase activity IMP
IMP: Inferred from mutant phenotype
17595219 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
19889946 MGI
enables phosphofructokinase activity IDA
IDA: Inferred from direct assay
11785984 MGI
Biological Process GO Annotation Evidence Reference Source
involved in canonical glycolysis IDA
IDA: Inferred from direct assay
4275392 MGI
involved in canonical glycolysis IGI
IGI: Inferred from genetic interaction
27760309 MGI
acts upstream of or within canonical glycolysis IMP
IMP: Inferred from mutant phenotype
19696889 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
17595219 MGI
acts upstream of or within glycogen catabolic process IMP
IMP: Inferred from mutant phenotype
19696889 MGI
acts upstream of or within glycolysis from storage polysaccharide through glucose-1-phosphate IMP
IMP: Inferred from mutant phenotype
19696889 MGI
acts upstream of or within glycolytic process through fructose-6-phosphate IDA
IDA: Inferred from direct assay
2521854 MGI
involved in glycolytic process through fructose-6-phosphate IDA
IDA: Inferred from direct assay
19889946 MGI
acts upstream of or within glycolytic process through fructose-6-phosphate IMP
IMP: Inferred from mutant phenotype
17595219 MGI
acts upstream of or within positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17595219 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
2521854 MGI
located in cytosol IDA
IDA: Inferred from direct assay
2521854 MGI
located in sperm principal piece IDA
IDA: Inferred from direct assay
19889946 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent 6-phosphofructokinase, muscle type

6-phosphofructokinase type A

6-phosphofructokinase, muscle type

phosphofructo-1-kinase isozyme A

phosphofructokinase 1

phosphofructokinase 4

phosphofructokinase M variant 3/4

phosphofructokinase, polypeptide X

phosphofructokinase-1 A isozyme

phosp

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10366 PFKM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18964 Pfkm Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25454 Pfkm Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkm NCBI NCBI:5213