Per2 - period circadian clock 2 Gene

Mus musculus

Also known as mPer2; mKIAA0347

Gene ID: 18627 | Gene type: protein coding

About Per2

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]

Per2 Products(1)

mRNA	Protein	Name
NM_011066.3	NP_035196.2	period circadian protein homolog 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	20159955	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21768648	MGI
enables RNA polymerase binding	IPI IPI: Inferred from physical interaction	22767893	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	24413057	MGI
enables histone methyltransferase binding	IPI IPI: Inferred from physical interaction	24413057	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	19402751	MGI
enables kinase binding	IPI IPI: Inferred from physical interaction	14701732	MGI
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	20159955	MGI
enables pre-mRNA binding	IDA IDA: Inferred from direct assay	22767893	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9856465	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21680841	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	20159955	MGI
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	24413057	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	21680841	MGI
involved in circadian regulation of gene expression	IDA IDA: Inferred from direct assay	20159955	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11395012	MGI
acts upstream of or within circadian rhythm	IDA IDA: Inferred from direct assay	12843397	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	14645221	MGI
involved in fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	23977055	MGI
involved in gluconeogenesis	IMP IMP: Inferred from mutant phenotype	22504074	MGI
involved in glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	20159955	MGI
involved in lactate biosynthetic process	IMP IMP: Inferred from mutant phenotype	23977055	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12738229	MGI
involved in negative regulation of circadian rhythm	IDA IDA: Inferred from direct assay	19605937	MGI
involved in negative regulation of fat cell proliferation	IMP IMP: Inferred from mutant phenotype	21035761	MGI
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	11889036	MGI
involved in negative regulation of termination of DNA-templated transcription	IDA IDA: Inferred from direct assay	22767893	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9989497	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21035761	MGI
involved in negative regulation of transcription regulatory region DNA binding	IMP IMP: Inferred from mutant phenotype	21035761	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24049733	MGI
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	24268780	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	11395012	MGI
involved in regulation of glutamate uptake involved in transmission of nerve impulse	IMP IMP: Inferred from mutant phenotype	16595674	MGI
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	22504074	MGI
involved in regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	24268780	MGI
involved in regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17404161	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	23977055	MGI
involved in white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	21035761	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cry-Per complex	IPI IPI: Inferred from physical interaction	20840750	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11889036	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11889036	MGI
located in nucleus	IPI IPI: Inferred from physical interaction	15689618	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	22274616	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

period circadian protein homolog 2

circadian clock protein PERIOD 2	period 2
period homolog 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119506	KL044		99.05%	Unkown
HY-RS10332	PER2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20323	Per2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26831	Per2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Per2	NCBI	NCBI:8864

Name
Email *

	Sorry, but the email address you supplied was invalid.