2. Gene
  3. Pcsk1 - proprotein convertase subtilisin/kexin type 1 Gene

Pcsk1 - proprotein convertase subtilisin/kexin type 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PC1; PC3; Nec1; SPC3; Nec-1; Phpp-1

Gene ID: 18548 | Gene type: protein coding

About Pcsk1

Summary

Enables identical protein binding activity and serine-type endopeptidase activity. Involved in peptide biosynthetic process and peptide hormone processing. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; female reproductive system; and nose. Used to study obesity. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk1 Products(1)

mRNA Protein Name
NM_013628.3 NP_038656.1 neuroendocrine convertase 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
9242664 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
19376969 MGI
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
8262946 MGI
enables serine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
12136131 MGI
Biological Process GO Annotation Evidence Reference Source
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
12136131 MGI
involved in peptide biosynthetic process IDA
IDA: Inferred from direct assay
8262946 MGI
involved in peptide hormone processing IDA
IDA: Inferred from direct assay
8262946 MGI
involved in protein processing IDA
IDA: Inferred from direct assay
9242664 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
8397508 MGI
is active in secretory granule IDA
IDA: Inferred from direct assay
12136131 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroendocrine convertase 1

furin homolog

prohormone convertase 1

prohormone convertase 1/3

propeptide-processing protease

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10170 PCSK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10171 PCSK1N Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18538 Pcsk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25020 Pcsk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk1 NCBI NCBI:5122