Pck1 - phosphoenolpyruvate carboxykinase 1, cytosolic Gene

Mus musculus

Also known as PEPCK; Pck-1; PEPCK-C

Gene ID: 18534 | Gene type: protein coding

About Pck1

Summary

Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in oxaloacetate metabolic process and positive regulation of memory T cell differentiation. Acts upstream of or within several processes, including cellular response to potassium ion starvation; gluconeogenesis; and glycerol biosynthetic process from pyruvate. Located in cytosol. Is expressed in several structures, including alimentary system; brown fat; liver; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pck1 Products(1)

mRNA	Protein	Name
NM_011044.3	NP_035174.1	phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphoenolpyruvate carboxykinase (GTP) activity	IMP IMP: Inferred from mutant phenotype	10938127	MGI
enables phosphoenolpyruvate carboxykinase activity	IMP IMP: Inferred from mutant phenotype	11792850	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to potassium ion starvation	IDA IDA: Inferred from direct assay	19458124	MGI
acts upstream of or within gluconeogenesis	IDA IDA: Inferred from direct assay	11916968	MGI
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	19643083	MGI
involved in gluconeogenesis	IMP IMP: Inferred from mutant phenotype	10938127	MGI
involved in glyceraldehyde-3-phosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	11792850	MGI
acts upstream of or within glycerol biosynthetic process from pyruvate	IMP IMP: Inferred from mutant phenotype	11792850	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	11792850	MGI
involved in oxaloacetate metabolic process	IMP IMP: Inferred from mutant phenotype	29230018	MGI
involved in positive regulation of memory T cell differentiation	IMP IMP: Inferred from mutant phenotype	29230018	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19458124	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	19458124	MGI
located in cytosol	IDA IDA: Inferred from direct assay	19458124	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphoenolpyruvate carboxykinase, cytosolic [GTP]

phosphoenolpyruvate carboxykinase, cytosolic	phosphoenolpyruvate carboxylase
serine-protein kinase PCK1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-175266	MI1013		/	Unkown
HY-RS10152	PCK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17590	Pck1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24050	Pck1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pck1	NCBI	NCBI:5105

Name
Email *

	Sorry, but the email address you supplied was invalid.