Pbx3 - pre B cell leukemia homeobox 3 Gene

Mus musculus

Gene ID: 18516 | Gene type: protein coding

About Pbx3

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult locomotory behavior; nervous system development; and regulation of respiratory gaseous exchange by nervous system process. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Orthologous to human PBX3 (PBX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]

Pbx3 Products(2)

mRNA	Protein	Name
NM_001290576.1	NP_001277505.1	pre-B-cell leukemia transcription factor 3 isoform PBX3b
NM_016768.2	NP_058048.1	pre-B-cell leukemia transcription factor 3 isoform PBX3a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15466398	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15466398	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10381567	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16847320	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	18155191	MGI
acts upstream of or within dorsal spinal cord development	IMP IMP: Inferred from mutant phenotype	18155191	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	18155191	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15466398	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IMP IMP: Inferred from mutant phenotype	15527896	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	15466398	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10842069	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	10381567	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pre-B-cell leukemia transcription factor 3

homeobox protein PBX3

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3245A	HXR9 hydrochloride		99.20%	Unkown
HY-P3245	HXR9	Inducer	/	Unkown
HY-RS10108	PBX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22270	Pbx3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pbx3	NCBI	NCBI:5090

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