Pax9 - paired box 9 Gene

Mus musculus

Also known as Pax-9

Gene ID: 18511 | Gene type: protein coding

About Pax9

Summary

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and Cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]

Pax9 Products(1)

mRNA	Protein	Name
NM_011041.3	NP_035171.1	paired box protein Pax-9

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	14607846	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	14607846	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15721141	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	9244299	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	11932925	MGI
acts upstream of or within face morphogenesis	IGI IGI: Inferred from genetic interaction	20123092	MGI
acts upstream of or within odontogenesis	IGI IGI: Inferred from genetic interaction	20123092	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14607846	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15024065	MGI
acts upstream of or within regulation of odontogenesis	IGI IGI: Inferred from genetic interaction	20123092	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paired box protein Pax-9

paired box gene 9

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10096	PAX9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22269	Pax9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28792	Pax9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax9	NCBI	NCBI:5083

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