Pax8 - paired box 8 Gene

Mus musculus

Also known as Pax-8

Gene ID: 18510 | Gene type: protein coding

About Pax8

Summary

This gene encodes a member of a family of transcription factors that contain a characteristic N-terminal paired DNA-binding domain. The encoded protein is important for proper differentiation of the thyroid and the kidney. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Mar 2013]

Pax8 Products(1)

mRNA	Protein	Name
NM_011040.4	NP_035170.1	paired box protein Pax-8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12441357	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17047028	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in S-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in central nervous system development	IEP IEP: Inferred from expression pattern	1723950	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	9590297	MGI
involved in inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	20727173	MGI
involved in kidney epithelium development	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in mesonephric tubule development	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in mesonephros development	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in mesonephros development	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in metanephric distal convoluted tubule development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in metanephric nephron tubule formation	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in metanephros development	IEP IEP: Inferred from expression pattern	1723950	MGI
acts upstream of or within metanephros development	IGI IGI: Inferred from genetic interaction	12435636	MGI
involved in negative regulation of apoptotic process involved in metanephric collecting duct development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in negative regulation of apoptotic process involved in metanephric nephron tubule development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22453009	MGI
involved in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8413205	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	16319112	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in positive regulation of metanephric DCT cell differentiation	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in positive regulation of thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	12586753	MGI
involved in pronephric field specification	IEP IEP: Inferred from expression pattern	12435636	MGI
involved in pronephros development	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in regulation of metanephric nephron tubule epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in thyroid gland development	IEP IEP: Inferred from expression pattern	1723950	MGI
acts upstream of or within thyroid gland development	IGI IGI: Inferred from genetic interaction	11773436	MGI
acts upstream of or within thyroid gland development	IMP IMP: Inferred from mutant phenotype	9590297	MGI
involved in urogenital system development	IGI IGI: Inferred from genetic interaction	12435636	MGI
involved in ventricular septum development	IMP IMP: Inferred from mutant phenotype	22453009	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	19010321	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

paired box protein Pax-8

paired box gene 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10095	PAX8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18962	Pax8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25453	Pax8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax8	NCBI	NCBI:7849

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