Ovol1 - ovo like zinc finger 1 Gene

Mus musculus

Also known as Ovo1; movo1

Gene ID: 18426 | Gene type: protein coding

About Ovol1

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of meiotic cell cycle. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Orthologous to human OVOL1 (ovo like transcriptional repressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ovol1 Products(1)

mRNA	Protein	Name
NM_019935.3	NP_064319.1	putative transcription factor Ovo-like 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17049212	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17311813	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17311813	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within epidermis development	IGI IGI: Inferred from genetic interaction	24735878	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	9808631	MGI
acts upstream of or within germline cell cycle switching, mitotic to meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	15716349	MGI
acts upstream of keratinocyte proliferation	IGI IGI: Inferred from genetic interaction	24735878	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	17049212	MGI
acts upstream of meiotic cell cycle phase transition	IMP IMP: Inferred from mutant phenotype	15716349	MGI
acts upstream of or within mesoderm development	IMP IMP: Inferred from mutant phenotype	9808631	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IGI IGI: Inferred from genetic interaction	24735878	MGI
acts upstream of or within negative regulation of meiotic cell cycle phase transition	IMP IMP: Inferred from mutant phenotype	15716349	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	24735878	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15716349	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17311813	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	17049212	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	9808631	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	24735878	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9808631	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

putative transcription factor Ovo-like 1

OVO homolog-like 1

mOvo1a

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09883	OVOL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21007	Ovol1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27524	Ovol1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ovol1	NCBI	NCBI:5017

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