2. Gene
  3. Cldn11 - claudin 11 Gene

Cldn11 - claudin 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Osp; Otm; Claudin11; Claudin-11

Gene ID: 18417 | Gene type: protein coding

About Cldn11

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of CNS (central nervous system) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. The basal cell tight junctions in stria vascularis are primarily composed of this protein, and the gene-null mice suffer severe deafness. This protein is also an obligatory protein for tight junction formation and barrier integrity in the testis and the gene deficiency results in loss of the Sertoli cell epithelial phenotype in the testis. [provided by RefSeq, Aug 2010]

Cldn11 Products(1)

mRNA Protein Name
NM_008770.3 NP_032796.1 claudin-11
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16267818 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within axon ensheathment IMP
IMP: Inferred from mutant phenotype
10612400 MGI
acts upstream of or within cell adhesion IMP
IMP: Inferred from mutant phenotype
10612400 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
10612400 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basal part of cell IDA
IDA: Inferred from direct assay
23789093 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
18308723 MGI
located in tight junction IDA
IDA: Inferred from direct assay
30734065 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-11

oligodendrocyte transmembrane protein

oligodendrocyte-specific protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02764 CLDN11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20144 Cldn11 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26648 Cldn11 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn11 NCBI NCBI:5010