2. Gene
  3. Nsd1 - nuclear receptor-binding SET-domain protein 1 Gene

Nsd1 - nuclear receptor-binding SET-domain protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as KMT3B

Gene ID: 18193 | Gene type: protein coding

About Nsd1

Summary

Enables several functions, including histone-lysine N-methyltransferase activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in histone methylation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within gastrulation with mouth forming second. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; long bone epiphysis; and retina. Human ortholog(s) of this gene implicated in Sotos syndrome; Sotos syndrome 1; acute myeloid leukemia; microcephaly; and neuroblastoma. Orthologous to human NSD1 (nuclear receptor binding SET domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nsd1 Products(19)

mRNA Protein Name
NM_001408698.1 NP_001395627.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2
NM_001408699.1 NP_001395628.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2
NM_001408700.1 NP_001395629.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 2
NM_001408701.1 NP_001395630.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 3
NM_001408702.1 NP_001395631.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408703.1 NP_001395632.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408704.1 NP_001395633.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408705.1 NP_001395634.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 4
NM_001408706.1 NP_001395635.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 5
NM_001408707.1 NP_001395636.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408708.1 NP_001395637.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 5
NM_001408709.1 NP_001395638.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408710.1 NP_001395639.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408711.1 NP_001395640.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408712.1 NP_001395641.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 6
NM_001408713.1 NP_001395642.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7
NM_001408714.1 NP_001395643.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 7
NM_001408715.1 NP_001395644.1 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 8
NM_008739.3 NP_032765.3 histone-lysine N-methyltransferase, H3 lysine-36 specific isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
15522233 MGI
enables histone H3K36 methyltransferase activity IDA
IDA: Inferred from direct assay
12805229 MGI
enables histone H4K20 methyltransferase activity IDA
IDA: Inferred from direct assay
12805229 MGI
enables histone methyltransferase activity IDA
IDA: Inferred from direct assay
12805229 MGI
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
9628876 MGI
enables nuclear retinoic acid receptor binding IPI
IPI: Inferred from physical interaction
9628876 MGI
enables nuclear retinoid X receptor binding IPI
IPI: Inferred from physical interaction
9628876 MGI
enables nuclear thyroid hormone receptor binding IPI
IPI: Inferred from physical interaction
9628876 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15169884 MGI
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
9628876 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
9628876 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
12805229 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9628876 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
18157086 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase, H3 lysine-36 specific

H3-K36-HMTase

H4-K20-HMTase

NR-binding SET domain-containing protein

histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

nuclear receptor-binding SET domain-containing protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-134086 NSD-IN-2 Inhibitor 97.76% Unkown
HY-121093 DC-S239 Inhibitor 99.73% Unkown
HY-125244 LEM-14-1189 Inhibitor 99.57% Unkown
HY-RS09587 NSD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18628 Nsd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25114 Nsd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nsd1 NCBI NCBI:64324