Nrxn1 - neurexin I Gene

Mus musculus

Also known as mKIAA0578; 1700062G21Rik; 9330127H16Rik; A230068P09Rik

Gene ID: 18189 | Gene type: protein coding

About Nrxn1

Summary

This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]

Nrxn1 Products(23)

mRNA	Protein	Name
NM_001346957.1	NP_001333886.1	neurexin-1 isoform 3 precursor
NM_001346958.2	NP_001333887.1	neurexin-1 isoform 4 precursor
NM_001346959.2	NP_001333888.1	neurexin-1 isoform 5 precursor
NM_001346960.2	NP_001333889.1	neurexin-1 isoform 6
NM_001346961.2	NP_001333890.1	neurexin-1 isoform 7
NM_001346962.2	NP_001333891.1	neurexin-1 isoform 8
NM_001347419.2	NP_001334348.1	neurexin-1 isoform 9
NM_001403319.1	NP_001390248.1	neurexin-1 isoform 18 precursor
NM_001403320.1	NP_001390249.1	neurexin-1 isoform 20 precursor
NM_001403321.1	NP_001390250.1	neurexin-1 isoform 19 precursor
NM_001403322.1	NP_001390251.1	neurexin-1 isoform 18 precursor
NM_001403323.1	NP_001390252.1	neurexin-1 isoform 17 precursor
NM_001403324.1	NP_001390253.1	neurexin-1 isoform 16 precursor
NM_001403325.1	NP_001390254.1	neurexin-1 isoform 15 precursor
NM_001403326.1	NP_001390255.1	neurexin-1 isoform 14 precursor
NM_001403327.1	NP_001390256.1	neurexin-1 isoform 13 precursor
NM_001403328.1	NP_001390257.1	neurexin-1 isoform 12 precursor
NM_001403329.1	NP_001390258.1	neurexin-1 isoform 12 precursor
NM_001403330.1	NP_001390259.1	neurexin-1 isoform 11 precursor
NM_001403331.1	NP_001390260.1	neurexin-1 isoform 11 precursor
NM_001403332.1	NP_001390261.1	neurexin-1 isoform 10 precursor
NM_020252.4	NP_064648.3	neurexin-1 isoform 1 precursor
NM_177284.3	NP_796258.2	neurexin-1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylcholine receptor binding	IDA IDA: Inferred from direct assay	19567877	MGI
enables calcium channel regulator activity	IGI IGI: Inferred from genetic interaction	12827191	MGI
enables calcium-dependent protein binding	IDA IDA: Inferred from direct assay	19098102	MGI
enables cell adhesion molecule binding	IPI IPI: Inferred from physical interaction	12796785	MGI
enables neuroligin family protein binding	IPI IPI: Inferred from physical interaction	12796785	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19816407	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	12796785	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of AMPA selective glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	19098102	MGI
involved in NMDA glutamate receptor clustering	IDA IDA: Inferred from direct assay	15620359	MGI
acts upstream of NMDA selective glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	19098102	MGI
acts upstream of adult behavior	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	12796785	MGI
involved in cerebellar granule cell differentiation	IGI IGI: Inferred from genetic interaction	20537373	MGI
acts upstream of or within chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	12827191	MGI
involved in establishment of protein localization	IDA IDA: Inferred from direct assay	12796785	MGI
involved in filopodium assembly	IMP IMP: Inferred from mutant phenotype	20869594	MGI
involved in gamma-aminobutyric acid receptor clustering	IDA IDA: Inferred from direct assay	15620359	MGI
involved in gephyrin clustering involved in postsynaptic density assembly	IDA IDA: Inferred from direct assay	15620359	MGI
involved in guanylate kinase-associated protein clustering	IDA IDA: Inferred from direct assay	15620359	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA IDA: Inferred from direct assay	12796785	MGI
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IGI IGI: Inferred from genetic interaction	20537373	MGI
acts upstream of learning	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in negative regulation of filopodium assembly	IDA IDA: Inferred from direct assay	20869594	MGI
involved in neuroligin clustering involved in postsynaptic membrane assembly	IDA IDA: Inferred from direct assay	15620359	MGI
acts upstream of neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in neuron cell-cell adhesion	IDA IDA: Inferred from direct assay	12796785	MGI
involved in neuron maturation	IDA IDA: Inferred from direct assay	15620359	MGI
acts upstream of or within neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	12827191	MGI
involved in positive regulation of excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	19098102	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	19098102	MGI
acts upstream of or within positive regulation of synapse assembly	IGI IGI: Inferred from genetic interaction	21356198	MGI
acts upstream of or within positive regulation of synapse maturation	IDA IDA: Inferred from direct assay	19567877	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	19098102	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in postsynaptic density protein 95 clustering	IDA IDA: Inferred from direct assay	15620359	MGI
involved in postsynaptic membrane assembly	IDA IDA: Inferred from direct assay	15620359	MGI
involved in prepulse inhibition	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in presynapse assembly	IDA IDA: Inferred from direct assay	21410790	MGI
involved in presynapse assembly	IMP IMP: Inferred from mutant phenotype	21410790	MGI
involved in presynaptic membrane assembly	IDA IDA: Inferred from direct assay	12796785	MGI
involved in protein localization to synapse	IDA IDA: Inferred from direct assay	12796785	MGI
involved in protein-containing complex assembly involved in synapse maturation	IDA IDA: Inferred from direct assay	12796785	MGI
involved in receptor localization to synapse	IDA IDA: Inferred from direct assay	15620359	MGI
acts upstream of regulation of grooming behavior	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	21410790	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	21410790	MGI
involved in regulation of postsynaptic specialization assembly	IDA IDA: Inferred from direct assay	15620359	MGI
involved in regulation of postsynaptic specialization assembly	IMP IMP: Inferred from mutant phenotype	15620359	MGI
involved in regulation of presynapse assembly	IDA IDA: Inferred from direct assay	17360903	MGI
involved in regulation of presynapse assembly	IMP IMP: Inferred from mutant phenotype	17360903	MGI
involved in regulation of synaptic vesicle cycle	IDA IDA: Inferred from direct assay	19822762	MGI
involved in regulation of synaptic vesicle cycle	IMP IMP: Inferred from mutant phenotype	19822762	MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA IDA: Inferred from direct assay	26213384	MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	26213384	MGI
involved in signal transduction	IDA IDA: Inferred from direct assay	12796785	MGI
involved in synapse assembly	IDA IDA: Inferred from direct assay	31995730	MGI
acts upstream of synapse assembly	IGI IGI: Inferred from genetic interaction	21356198	MGI
acts upstream of or within synapse assembly	IGI IGI: Inferred from genetic interaction	12827191	MGI
involved in synapse assembly	IMP IMP: Inferred from mutant phenotype	31995730	MGI
involved in synaptic membrane adhesion	IDA IDA: Inferred from direct assay	12796785	MGI
involved in synaptic membrane adhesion	IMP IMP: Inferred from mutant phenotype	12796785	MGI
involved in synaptic vesicle clustering	IDA IDA: Inferred from direct assay	12796785	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IDA IDA: Inferred from direct assay	36205393	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IEP IEP: Inferred from expression pattern	36205393	MGI
involved in trans-synaptic signaling, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	36205393	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	15620359	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	15620359	MGI
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	19036990	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	19036990	MGI
located in axonal growth cone	IDA IDA: Inferred from direct assay	12796785	MGI
located in cell surface	IDA IDA: Inferred from direct assay	19098102	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19036990	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15620359	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	36205393	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15620359	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	19036990	MGI
located in nuclear membrane	IDA IDA: Inferred from direct assay	19036990	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	17360903	MGI
is active in presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	17360903	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	19036990	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12827191	MGI
is active in presynaptic membrane	IMP IMP: Inferred from mutant phenotype	19036990	MGI
part of protein complex involved in cell-cell adhesion	EXP EXP: Inferred from Experiment	18084303	MGI
part of protein-containing complex	IPI IPI: Inferred from physical interaction	24613359	MGI
part of trans-synaptic protein complex	IDA IDA: Inferred from direct assay	34135511	MGI
located in vesicle	IDA IDA: Inferred from direct assay	19036990	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurexin-1

alpha-latrotoxin receptor (calcium-dependent)	neurexin 1 NRXN1+7a
neurexin 1 NRXN1-7

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09583	NRXN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21669	Nrxn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28187	Nrxn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nrxn1	NCBI	NCBI:9378

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