Slc11a1 - solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Gene

Mus musculus

Also known as Bcg; Ity; Lsh; ity; Ity1; Nramp; Nramp1

Gene ID: 18173 | Gene type: protein coding

About Slc11a1

Summary

Enables manganese ion transmembrane transporter activity. Involved in metal ion export. Acts upstream of or within several processes, including cation homeostasis; defense response to Other organism; and positive regulation of macromolecule metabolic process. Located in cytoplasmic vesicle and lysosome. Is expressed in several structures, including brain; gut; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc11a1 Products(1)

mRNA	Protein	Name
NM_013612.2	NP_038640.2	natural resistance-associated macrophage protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables iron ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9730978	MGI
enables manganese ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9730978	MGI
enables manganese ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	11067873	MGI
enables metal cation:proton antiporter activity	IDA IDA: Inferred from direct assay	9730978	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within L-arginine transmembrane transport	IDA IDA: Inferred from direct assay	8529105	MGI
acts upstream of or within MHC class II biosynthetic process	IMP IMP: Inferred from mutant phenotype	8301134	MGI
acts upstream of or within T cell cytokine production	IMP IMP: Inferred from mutant phenotype	19116231	MGI
acts upstream of or within T cell proliferation involved in immune response	IMP IMP: Inferred from mutant phenotype	9176118	MGI
acts upstream of or within activation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	8301134	MGI
acts upstream of or within antigen processing and presentation of peptide antigen	IMP IMP: Inferred from mutant phenotype	17620357	MGI
acts upstream of or within defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	6358358	MGI
acts upstream of or within defense response to bacterium	IMP IMP: Inferred from mutant phenotype	385184	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	606434	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	11067873	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	19116231	MGI
acts upstream of or within interleukin-2 production	IMP IMP: Inferred from mutant phenotype	9176118	MGI
acts upstream of or within interleukin-3 production	IMP IMP: Inferred from mutant phenotype	9176118	MGI
acts upstream of or within intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	11903051	MGI
involved in iron ion transport	IDA IDA: Inferred from direct assay	9730978	MGI
acts upstream of or within mRNA stabilization	IMP IMP: Inferred from mutant phenotype	9009318	MGI
acts upstream of or within macrophage activation	IDA IDA: Inferred from direct assay	8529105	MGI
acts upstream of or within macrophage activation	IMP IMP: Inferred from mutant phenotype	19116231	MGI
involved in manganese ion transport	IDA IDA: Inferred from direct assay	9730978	MGI
acts upstream of or within manganese ion transport	IMP IMP: Inferred from mutant phenotype	11067873	MGI
involved in metal ion transport	IDA IDA: Inferred from direct assay	17932044	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	9824471	MGI
acts upstream of or within negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	16470178	MGI
acts upstream of or within nitrite transport	IDA IDA: Inferred from direct assay	8529105	MGI
acts upstream of or within phagocytosis	IMP IMP: Inferred from mutant phenotype	18045875	MGI
acts upstream of or within positive regulation of T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	18984740	MGI
acts upstream of or within positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	1541907	MGI
acts upstream of or within positive regulation of dendritic cell antigen processing and presentation	IMP IMP: Inferred from mutant phenotype	18984740	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16470178	MGI
acts upstream of or within positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	18456389	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17620357	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	18984740	MGI
acts upstream of or within respiratory burst	IDA IDA: Inferred from direct assay	8529105	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	8490962	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	9261342	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17620357	MGI
acts upstream of or within response to type II interferon	IDA IDA: Inferred from direct assay	9261342	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	18984740	MGI
acts upstream of or within vacuolar acidification	IMP IMP: Inferred from mutant phenotype	9670047	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	16470178	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome membrane	IDA IDA: Inferred from direct assay	9034150	MGI
located in late endosome	IDA IDA: Inferred from direct assay	17620357	MGI
located in late endosome	IMP IMP: Inferred from mutant phenotype	9034150	MGI
located in late endosome membrane	IDA IDA: Inferred from direct assay	9730978	MGI
located in lysosomal membrane	IDA IDA: Inferred from direct assay	9730978	MGI
located in lysosome	IDA IDA: Inferred from direct assay	17620357	MGI
located in phagocytic vesicle membrane	IDA IDA: Inferred from direct assay	9034150	MGI
located in phagocytic vesicle membrane	IMP IMP: Inferred from mutant phenotype	11067873	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

natural resistance-associated macrophage protein 1

NRAMP 1	host resistance locus Bcg/Ity/Lsh
solute carrier family 11 member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12994	SLC11A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19551	Slc11a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26047	Slc11a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc11a1	NCBI	NCBI:6556

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