2. Gene
  3. Pnoc - prepronociceptin Gene

Pnoc - prepronociceptin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as N/OFQ; Npnc1; OFQ/N

Gene ID: 18155 | Gene type: protein coding

About Pnoc

Summary

This gene encodes the precursor for neuropeptides that have been implicated in a wide range of physiological roles such as transmission and sensitivity to pain, learning, memory, anxiety and depression, in the central nervous system. The encoded protein is a precursor that is proteolytically processed to generate multiple biologically active peptides including nociceptin and nocistatin which have opposite functions in pain transmission. Mice lacking the encoded protein display increased anxiety, elevated basal pain threshold and impaired adaptation to repeated stress. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Pnoc Products(2)

mRNA Protein Name
NM_001205075.1 NP_001192004.1 prepronociceptin isoform 2 preproprotein
NM_010932.2 NP_035062.1 prepronociceptin isoform 1 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables receptor ligand activity IGI
IGI: Inferred from genetic interaction
19448152 MGI
Biological Process GO Annotation Evidence Reference Source
involved in neuron-neuron synaptic transmission IGI
IGI: Inferred from genetic interaction
22311985 MGI
involved in sensory perception of pain IGI
IGI: Inferred from genetic interaction
19448152 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in synaptic membrane IGI
IGI: Inferred from genetic interaction
22311985 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prepronociceptin

neuropeptide nociceptin 1

orphanin FQ

proorphanin

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10788 PNOC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22283 Pnoc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnoc NCBI NCBI:5368