Nfatc1 - nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 Gene

Mus musculus

Also known as NFAT2; NFATc; NF-ATc; Nfatcb; 2210017P03Rik

Gene ID: 18018 | Gene type: protein coding

About Nfatc1

Summary

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; branching involved in lymph vessel morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; eye; genitourinary system; and heart. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc1 Products(6)

mRNA	Protein	Name
NM_001164109.1	NP_001157581.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform 3
NM_001164110.1	NP_001157582.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform 4
NM_001164111.1	NP_001157583.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform 6
NM_001164112.1	NP_001157584.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform 5
NM_016791.4	NP_058071.2	nuclear factor of activated T-cells, cytoplasmic 1 isoform 1
NM_198429.2	NP_940821.1	nuclear factor of activated T-cells, cytoplasmic 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	23980096	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15304486	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15304486	MGI
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	11889139	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18408153	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15304486	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15304486	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24301466	MGI
enables mitogen-activated protein kinase p38 binding	IPI IPI: Inferred from physical interaction	15304486	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15380363	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7650004	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B-1a B cell differentiation	IMP IMP: Inferred from mutant phenotype	14595020	MGI
acts upstream of or within G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12660151	MGI
involved in aortic valve development	IMP IMP: Inferred from mutant phenotype	22300732	MGI
acts upstream of or within aortic valve morphogenesis	IMP IMP: Inferred from mutant phenotype	9515964	MGI
acts upstream of or within branching involved in lymph vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	19233265	MGI
acts upstream of or within calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	19233265	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	12660151	MGI
acts upstream of or within cell quiescence	IMP IMP: Inferred from mutant phenotype	18243104	MGI
acts upstream of or within cellular response to calcium ion	IDA IDA: Inferred from direct assay	23259949	MGI
involved in endocardial cushion development	IGI IGI: Inferred from genetic interaction	22300732	MGI
acts upstream of or within epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	15339668	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	23259949	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15339668	MGI
acts upstream of or within heart trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	9515963	MGI
involved in heart valve development	IMP IMP: Inferred from mutant phenotype	22300732	MGI
acts upstream of or within heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	9515963	MGI
acts upstream of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	18243104	MGI
acts upstream of or within lymphangiogenesis	IGI IGI: Inferred from genetic interaction	19233265	MGI
acts upstream of or within negative regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	18243104	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	19463978	MGI
acts upstream of or within negative regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18243104	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19463978	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19463978	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18243104	MGI
acts upstream of or within osteoclast differentiation	IGI IGI: Inferred from genetic interaction	21982707	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	22451653	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12808150	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15304486	MGI
involved in pulmonary valve development	IMP IMP: Inferred from mutant phenotype	22300732	MGI
acts upstream of or within pulmonary valve morphogenesis	IMP IMP: Inferred from mutant phenotype	9515964	MGI
acts upstream of or within regulation of hair cycle	IMP IMP: Inferred from mutant phenotype	18243104	MGI
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22019888	MGI
involved in semi-lunar valve development	IMP IMP: Inferred from mutant phenotype	22300732	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18243104	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19233265	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19463978	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18243104	MGI
acts upstream of or within transition between fast and slow fiber	IMP IMP: Inferred from mutant phenotype	18408153	MGI
acts upstream of or within ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	9515964	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	23259949	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10903175	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	23259949	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9515963	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	19561615	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 1

NF-ATc1	NFAT transcription complex cytosolic component
transcription factor NF-ATc

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113756A	Latanoprost acid	Inhibitor	99.62%	Unkown

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0656	Usnic acid		98.90%	Unkown
HY-N2119	Sciadopitysin	Inhibitor	≥99.0%	Unkown
HY-147369	NFATc1-IN-1	Inhibitor	99.97%	Unkown
HY-N0231	Bavachalcone		99.95%	Unkown
HY-N2157	Pteryxin	Inhibitor	99.96%	Unkown
HY-123503	Salicortin	Inhibitor	/	Unkown
HY-124958	NDMC101	Inhibitor	99.91%	Unkown
HY-149852	Anti-osteoporosis agent-3		/	Unkown
HY-162280	PROTAC BTK Degrader-9		/	Unkown
HY-N12604	Penicisteck acid F	Inhibitor	/	Unkown
HY-N2528	Usnic acid sodium	Inhibitor	/	Unkown
HY-N3071	Picrasidine I		/	Unkown
HY-P4684	Osteostatin		/	Unkown
HY-RS09238	NFATC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W641445	ELP-004	Inhibitor	/	Unkown
HY-RS18427	Nfatc1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24908	Nfatc1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfatc1	NCBI	NCBI:4772

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