Nf1 - neurofibromin 1 Gene

Mus musculus

Also known as Dsk9; Nf-1; Mhdadsk9; E030030H24Rik

Gene ID: 18015 | Gene type: protein coding

About Nf1

Summary

Enables GTPase activator activity. Involved in negative regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; modulation of chemical synaptic transmission; and nervous system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Used to study juvenile myelomonocytic leukemia and neurofibromatosis. Human ortholog(s) of this gene implicated in autistic disorder; hematologic Cancer (multiple); nervous system Cancer (multiple); neurofibromatosis 1; and neurofibromatosis-Noonan syndrome. Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Apr 2022]

Nf1 Products(1)

mRNA	Protein	Name
NM_010897.2	NP_035027.1	neurofibromin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IGI IGI: Inferred from genetic interaction	15665300	MGI
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	8563750	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16405917	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16644864	MGI
acts upstream of or within MAPK cascade	IMP IMP: Inferred from mutant phenotype	14724565	MGI
acts upstream of Rac protein signal transduction	IGI IGI: Inferred from genetic interaction	15665300	MGI
acts upstream of Ras protein signal transduction	IGI IGI: Inferred from genetic interaction	15665300	MGI
acts upstream of or within Ras protein signal transduction	IGI IGI: Inferred from genetic interaction	10845775	MGI
acts upstream of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	11246230	MGI
acts upstream of or within Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	8563750	MGI
acts upstream of or within Schwann cell development	IMP IMP: Inferred from mutant phenotype	9001241	MGI
acts upstream of Schwann cell migration	IGI IGI: Inferred from genetic interaction	14724565	MGI
acts upstream of Schwann cell migration	IMP IMP: Inferred from mutant phenotype	14724565	MGI
acts upstream of Schwann cell proliferation	IGI IGI: Inferred from genetic interaction	9001241	MGI
acts upstream of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	9001241	MGI
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	15665300	MGI
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	16405917	MGI
acts upstream of or within adrenal gland development	IMP IMP: Inferred from mutant phenotype	16906226	MGI
acts upstream of or within amygdala development	IGI IGI: Inferred from genetic interaction	25242307	MGI
acts upstream of angiogenesis	IGI IGI: Inferred from genetic interaction	16648142	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	15944386	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9878702	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	10419687	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of or within cell communication	IMP IMP: Inferred from mutant phenotype	10442636	MGI
acts upstream of cell migration	IGI IGI: Inferred from genetic interaction	14724565	MGI
acts upstream of cell migration	IMP IMP: Inferred from mutant phenotype	14724565	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	9001241	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8563750	MGI
acts upstream of or within cellular response to heat	IDA IDA: Inferred from direct assay	20661302	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	11297510	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	10383727	MGI
acts upstream of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16288202	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	16835260	MGI
acts upstream of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	15039234	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IGI IGI: Inferred from genetic interaction	15039234	MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	15039234	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	10383727	MGI
acts upstream of or within forebrain astrocyte development	IMP IMP: Inferred from mutant phenotype	15944386	MGI
acts upstream of or within forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	11297510	MGI
acts upstream of or within gamma-aminobutyric acid secretion, neurotransmission	IGI IGI: Inferred from genetic interaction	25242307	MGI
acts upstream of glial cell proliferation	IGI IGI: Inferred from genetic interaction	10973261	MGI
acts upstream of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	10442636	MGI
acts upstream of or within glutamate secretion, neurotransmission	IGI IGI: Inferred from genetic interaction	25242307	MGI
acts upstream of or within hair follicle maturation	IMP IMP: Inferred from mutant phenotype	25340873	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	7920653	MGI
acts upstream of leukocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	17053831	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of or within long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	16271875	MGI
acts upstream of or within long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16271875	MGI
acts upstream of mast cell apoptotic process	IGI IGI: Inferred from genetic interaction	15039234	MGI
acts upstream of mast cell proliferation	IGI IGI: Inferred from genetic interaction	10620616	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of or within myelination in peripheral nervous system	IMP IMP: Inferred from mutant phenotype	10586246	MGI
acts upstream of myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17053831	MGI
acts upstream of myeloid leukocyte migration	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within negative regulation of MAP kinase activity	IGI IGI: Inferred from genetic interaction	10620616	MGI
acts upstream of or within negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	11297510	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16644864	MGI
acts upstream of or within negative regulation of Rac protein signal transduction	IGI IGI: Inferred from genetic interaction	15665300	MGI
acts upstream of or within negative regulation of Ras protein signal transduction	IGI IGI: Inferred from genetic interaction	15665300	MGI
acts upstream of or within negative regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	11246230	MGI
acts upstream of or within negative regulation of Schwann cell migration	IGI IGI: Inferred from genetic interaction	14724565	MGI
acts upstream of or within negative regulation of Schwann cell migration	IMP IMP: Inferred from mutant phenotype	14724565	MGI
acts upstream of or within negative regulation of Schwann cell proliferation	IGI IGI: Inferred from genetic interaction	9001241	MGI
acts upstream of or within negative regulation of Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	9001241	MGI
acts upstream of or within negative regulation of angiogenesis	IGI IGI: Inferred from genetic interaction	16648142	MGI
acts upstream of or within negative regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	9878702	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10591652	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8563750	MGI
acts upstream of or within negative regulation of cell-matrix adhesion	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within negative regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16288202	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	10383727	MGI
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	20154697	MGI
acts upstream of or within negative regulation of glial cell proliferation	IGI IGI: Inferred from genetic interaction	10973261	MGI
acts upstream of or within negative regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	10442636	MGI
acts upstream of or within negative regulation of leukocyte migration	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within negative regulation of mast cell proliferation	IGI IGI: Inferred from genetic interaction	10620616	MGI
acts upstream of or within negative regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of or within negative regulation of neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	16298082	MGI
acts upstream of or within negative regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	16298082	MGI
acts upstream of or within negative regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15944386	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within negative regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	12469121	MGI
acts upstream of or within negative regulation of protein kinase activity	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	16835260	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	10591653	MGI
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	10419687	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10845775	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	7671302	MGI
acts upstream of neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	16298082	MGI
acts upstream of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	16298082	MGI
acts upstream of or within observational learning	IGI IGI: Inferred from genetic interaction	25242307	MGI
acts upstream of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15944386	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	16893911	MGI
acts upstream of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	10419687	MGI
acts upstream of or within phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	14724565	MGI
acts upstream of or within pigmentation	IGI IGI: Inferred from genetic interaction	10620616	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	10594763	MGI
acts upstream of or within positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	8563750	MGI
acts upstream of or within positive regulation of adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	11788835	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15944386	MGI
acts upstream of or within positive regulation of endothelial cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	15039234	MGI
acts upstream of or within positive regulation of leukocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	17053831	MGI
acts upstream of or within positive regulation of mast cell apoptotic process	IGI IGI: Inferred from genetic interaction	15039234	MGI
acts upstream of or within positive regulation of myeloid cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17053831	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10845775	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	7671302	MGI
acts upstream of or within positive regulation of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	12469121	MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	16271875	MGI
acts upstream of or within regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	16271875	MGI
acts upstream of or within regulation of MAPK cascade	IGI IGI: Inferred from genetic interaction	25242307	MGI
acts upstream of or within regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	16288202	MGI
acts upstream of or within regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	17053831	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10678181	MGI
acts upstream of or within regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	16405917	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	25242307	MGI
acts upstream of or within regulation of glial cell differentiation	IMP IMP: Inferred from mutant phenotype	12904481	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IGI IGI: Inferred from genetic interaction	11793011	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11793011	MGI
acts upstream of or within regulation of long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	25242307	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	22105171	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	22105171	MGI
acts upstream of or within regulation of synaptic transmission, GABAergic	IGI IGI: Inferred from genetic interaction	11793011	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	16288202	MGI
acts upstream of or within skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of or within smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	16906226	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	10591653	MGI
acts upstream of or within sympathetic nervous system development	IMP IMP: Inferred from mutant phenotype	7926784	MGI
acts upstream of vascular associated smooth muscle cell migration	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of vascular associated smooth muscle cell proliferation	IGI IGI: Inferred from genetic interaction	16644864	MGI
acts upstream of or within visual learning	IGI IGI: Inferred from genetic interaction	9054942	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	11793011	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	10383727	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15133494	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22105171	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22105171	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurofibromin

neurofibromatosis 1

neurofibromatosis-related protein NF-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158115	NST-628	Inhibitor	98.61%	Unkown
HY-113821	1-Naphthyl phosphate potassium salt	Inhibitor	/	Unkown
HY-RS09233	NF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120614	BMS-186511	Inhibitor	/	Unkown
HY-156872	MTX-216		/	Unkown
HY-RS17398	Nf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23853	Nf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nf1	NCBI	NCBI:4763

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