Nedd9 - neural precursor cell expressed, developmentally down-regulated gene 9 Gene

Mus musculus

Also known as CasL; HEF1; MEF1; p105; Cas-L; Nedd-9

Gene ID: 18003 | Gene type: protein coding

About Nedd9

Summary

Predicted to enable protein tyrosine kinase binding activity. Acts upstream of or within activation of GTPase activity. Located in nucleus and spindle pole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb mesenchyme; and nose. Orthologous to human NEDD9 (neural precursor cell expressed, developmentally down-regulated 9). [provided by Alliance of Genome Resources, Apr 2022]

Nedd9 Products(2)

mRNA	Protein	Name
NM_001111324.2	NP_001104794.1	enhancer of filamentation 1 isoform 1
NM_017464.5	NP_059492.3	enhancer of filamentation 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20956287	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activation of GTPase activity	IGI IGI: Inferred from genetic interaction	25621495	MGI
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	26683084	MGI
involved in lymphocyte migration into lymphoid organs	IMP IMP: Inferred from mutant phenotype	16148091	MGI
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	25059660	MGI
involved in positive regulation of dendritic spine maintenance	IMP IMP: Inferred from mutant phenotype	26683084	MGI
involved in positive regulation of immunological synapse formation	IMP IMP: Inferred from mutant phenotype	27359298	MGI
involved in positive regulation of lymphocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	16148091	MGI
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	27336669	MGI
involved in positive regulation of protein localization	IMP IMP: Inferred from mutant phenotype	27359298	MGI
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27359298	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in immunological synapse	IDA IDA: Inferred from direct assay	27359298	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19376971	MGI
located in spindle pole	IDA IDA: Inferred from direct assay	19376971	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

enhancer of filamentation 1

CRK-associated substrate-related protein

Crk-associated substrate lymphocyte-specific protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09182	NEDD9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21663	Nedd9 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nedd9	NCBI	NCBI:4739

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