2. Gene
  3. Ndrg1 - N-myc downstream regulated gene 1 Gene

Ndrg1 - N-myc downstream regulated gene 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as RTP; DRG1; NMSL; Ndr1; Ndrl; TDD5; CAP43; CMT4D; HMSNL; PROXY1

Gene ID: 17988 | Gene type: protein coding

About Ndrg1

Summary

Predicted to enable Cadherin binding activity; small GTPase binding activity; and tubulin binding activity. Involved in negative regulation of cell population proliferation and peripheral nervous system myelin maintenance. Acts upstream of or within mast cell activation. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study Charcot-Marie-Tooth disease type 4D. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1). [provided by Alliance of Genome Resources, Apr 2022]

Ndrg1 Products(1)

mRNA Protein Name
NM_008681.2 NP_032707.2 protein NDRG1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within mast cell activation IDA
IDA: Inferred from direct assay
12804568 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23555679 MGI
involved in peripheral nervous system myelin maintenance IMP
IMP: Inferred from mutant phenotype
15082788 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15082788 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein NDRG1

N-myc downstream regulated 1

N-myc downstream-regulated gene 1 protein

protein Ndr1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125878 PROTAC SGK3 degrader-1 Inhibitor 99.89% Unkown
HY-RS09114 NDRG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17382 Ndrg1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23837 Ndrg1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ndrg1 NCBI NCBI:10397