Myh9 - myosin, heavy polypeptide 9, non-muscle Gene

Mus musculus

Also known as Fltn; Myhn1; Myhn-1; TU72.6; NMHCIIA; NMMHC-A; NMMHC-IIA

Gene ID: 17886 | Gene type: protein coding

About Myh9

Summary

Enables protein domain specific binding activity. Involved in several processes, including cortical granule exocytosis; negative regulation of actin filament severing; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within several processes, including establishment of T cell polarity; microtubule Cytoskeleton organization; and myoblast fusion. Located in several cellular components, including cortical granule; cytoskeleton; and immunological synapse. Part of Myosin II complex. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; early embryo; future spinal cord; heart and pericardium; and sensory organ. Used to study MYH-9 related disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (Myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]

Myh9 Products(1)

mRNA	Protein	Name
NM_022410.3	NP_071855.2	myosin-9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	28114272	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16407977	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	23325791	MGI

Biological Process GO Annotation	Evidence	Reference	Source
NOT involved in actin filament capping	IDA IDA: Inferred from direct assay	23325791	MGI
NOT involved in actin filament polymerization	IDA IDA: Inferred from direct assay	23325791	MGI
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	16407977	MGI
involved in cell morphogenesis	IMP IMP: Inferred from mutant phenotype	15292239	MGI
acts upstream of or within cell motility	IMP IMP: Inferred from mutant phenotype	15064761	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15292239	MGI
involved in cortical granule exocytosis	IMP IMP: Inferred from mutant phenotype	31118423	MGI
involved in endodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	15292239	MGI
acts upstream of or within establishment of T cell polarity	IMP IMP: Inferred from mutant phenotype	15064761	MGI
acts upstream of or within establishment of meiotic spindle localization	IDA IDA: Inferred from direct assay	9725909	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	15555549	MGI
acts upstream of or within meiotic spindle organization	IDA IDA: Inferred from direct assay	9725909	MGI
acts upstream of or within myoblast fusion	IMP IMP: Inferred from mutant phenotype	16895968	MGI
involved in negative regulation of actin filament severing	IMP IMP: Inferred from mutant phenotype	23325791	MGI
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	23325791	MGI
involved in positive regulation of protein processing in phagocytic vesicle	IMP IMP: Inferred from mutant phenotype	23325791	MGI
acts upstream of or within regulation of cell shape	IMP IMP: Inferred from mutant phenotype	16895968	MGI
acts upstream of or within uropod organization	IMP IMP: Inferred from mutant phenotype	15064761	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	15292239	MGI
located in brush border	IDA IDA: Inferred from direct assay	22114352	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	9725909	MGI
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	12893741	MGI
located in cortical granule	IDA IDA: Inferred from direct assay	31118423	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9725909	MGI
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	16895968	MGI
colocalizes with focal adhesion	IDA IDA: Inferred from direct assay	23325791	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	15064761	MGI
part of myosin II complex	IDA IDA: Inferred from direct assay	21126233	MGI
part of myosin complex	IDA IDA: Inferred from direct assay	8482409	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	16012337	MGI
located in spindle	IDA IDA: Inferred from direct assay	9725909	MGI
located in stress fiber	IDA IDA: Inferred from direct assay	16895968	MGI
located in uropod	IDA IDA: Inferred from direct assay	15064761	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myosin-9

NMHC II-A	NMMHC II-a
cellular myosin heavy chain, type A	flectin
myosin IIA	myosin heavy chain IX
non-muscle myosin heavy chain IIa

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08908	MYH9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18249	Myh9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24729	Myh9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myh9	NCBI	NCBI:4627

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