Ppp1r15a - protein phosphatase 1, regulatory subunit 15A Gene

Mus musculus

Also known as Gadd34; Myd116; 9630030H21

Gene ID: 17872 | Gene type: protein coding

About Ppp1r15a

Summary

Enables protein Phosphatase binding activity and protein Phosphatase regulator activity. Involved in several processes, including peptidyl-serine dephosphorylation; regulation of gene expression; and regulation of protein modification process. Acts upstream of or within endoplasmic reticulum unfolded protein response. Predicted to be located in several cellular components, including Golgi apparatus; cytosol; and mitochondrion. Predicted to be part of protein Phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Used to study thalassemia. Orthologous to human PPP1R15A (protein Phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r15a Products(1)

mRNA	Protein	Name
NM_008654.2	NP_032680.1	protein phosphatase 1 regulatory subunit 15A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	11381086	MGI
enables protein phosphatase regulator activity	IDA IDA: Inferred from direct assay	11381086	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	15601821	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11381086	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	14635196	MGI
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	14635196	MGI
involved in positive regulation of transcription by RNA polymerase I	IDA IDA: Inferred from direct assay	14635196	MGI
involved in regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IDA IDA: Inferred from direct assay	11381086	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11381086	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	15601821	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 15A

growth arrest and DNA damage-inducible protein GADD34	growth arrest and DNA-damage-inducible 34
myeloid differentiation primary response gene 116	myeloid differentiation primary response protein MyD116
protein phosphatase 1, regulatory (inhibitor) sub

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111022	Icerguastat	Inhibitor	99.93%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18956	(E/Z)-Icerguastat	Inhibitor	99.44%	Unkown
HY-110365	Icerguastat Carbonate	Inhibitor	/	Unkown
HY-18956B	(E/Z)-Icerguastat acetate	Inhibitor	/	Unkown
HY-RS10986	PPP1R15A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-18956A	(E/Z)-Icerguastat hydrochloride	Inhibitor	/	Unkown
HY-RS17569	Ppp1r15a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24029	Ppp1r15a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1r15a	NCBI	NCBI:23645

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