2. Gene
  3. Mx1 - MX dynamin-like GTPase 1 Gene

Mx1 - MX dynamin-like GTPase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Mx; Mx-1

Gene ID: 17857 | Gene type: protein coding

About Mx1

Summary

This gene encodes a member of the Mx protein family of large GTPases, and functions in the innate immunity system. Interferon alpha/beta treatment or viral Infection induces expression of this protein, which subsequently accumulates in the cytoplasm and inhibits viral replication. It has been shown to confer resistance to the Influenza Virus. This gene produces a functional protein in some feral mouse strains, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a deletion or a nonsense mutation that results in a non-functional gene product. [provided by RefSeq, Aug 2015]

Mx1 Products(1)

mRNA Protein Name
NM_010846.1 NP_034976.1 protein Mx1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11716541 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
11716541 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Mx1

interferon-induced GTP-binding protein Mx1

myxoma resistance protein 1

myxovirus (influenza virus) resistance 1

myxovirus (influenza) resistance 1 polypeptide

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106031 F-14512 97.48% Phase 2
HY-12098 Verubulin hydrochloride Inhibitor 98.71% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0167 Gynostemma Extract Inhibitor 99.92% Unkown
HY-123805 KIN1400 98.1% Unkown
HY-155113 PROTAC Hsp90α degrader 1 Degrader 98.30% Unkown
HY-14687 (rac)-Talazoparib Inhibitor / Unkown
HY-RS08859 MX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121372 Lactandrate / Unkown
HY-N14478 Saframycin Mx1 Inhibitor / Unkown
HY-RS18454 Mx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24935 Mx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mx1 NCBI NCBI:4599