2. Gene
  3. Muc1 - mucin 1, transmembrane Gene

Muc1 - mucin 1, transmembrane Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as EMA; CD227; Muc-1

Gene ID: 17829 | Gene type: protein coding

About Muc1

Summary

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Predicted to be involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and regulation of transcription, DNA-templated. Located in apical plasma membrane and cell surface. Is expressed in several structures, including brain; exocrine gland; genitourinary system; gut; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including allergic rhinitis; biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; and pancreatic Cancer (multiple). Orthologous to human MUC1 (Mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]

Muc1 Products(1)

mRNA Protein Name
NM_013605.2 NP_038633.1 mucin-1 precursor
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16472605 MGI
located in cell surface IDA
IDA: Inferred from direct assay
1569123 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mucin-1

episialin

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99591 Sontuzumab Inhibitor 99.66% Phase 2
HY-P99634 Gatipotuzumab 95.48% Phase 1
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1925A GO-203 TFA 99.28% Unkown
HY-P2508 MUC1, mucin core 99.85% Unkown
HY-E70290 N-Acetylgalactosaminyltransferase 1 Agonist / Unkown
HY-P1925B L-GO-203 TFA Inhibitor 98.69% Unkown
HY-136453A CR-1-30-B Control 99.92% Unkown
HY-158469 Disialylated Core 1 O-glycan (C1S(3,6)2), 2-AB labelled 98.91% Unkown
HY-160060 MA3 aptamer sodium Chemical 95.74% Unkown
HY-158467 Core 1 O-glycan (C1), 2AB labelled / Unkown
HY-158471 Core 1 O-glycan (C1) / Unkown
HY-160062 S2.2 aptamer sodium Chemical / Unkown
HY-P10701 Q11 peptide / Unkown
HY-P5472 Tumour-associated MUC1 epitope / Unkown
HY-RS08831 MUC1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16863 Muc1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23304 Muc1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99968 Clivatuzumab Inhibitor ≥99.0% Unkown
HY-P990831 Anti-MUC1/CD227 Antibody (C595 (NCRC48)) Inhibitor 95.00% Unkown
HY-P991317 BTH1704 Inhibitor / Unkown
HY-P991318 AR20.5 Inhibitor / Unkown
HY-P991319 TAB-004 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Muc1 NCBI NCBI:4582
Macaca fascicularis Muc1 NCBI NCBI:102123068