Mtf1 - metal response element binding transcription factor 1 Gene

Mus musculus

Also known as MTF-1; Thyls

Gene ID: 17764 | Gene type: protein coding

About Mtf1

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Histone Acetyltransferase binding activity. Involved in cellular response to zinc ion and transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II; response to cadmium ion; and response to oxidative stress. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; cardiovascular system; early conceptus; genitourinary system; and gut. Orthologous to human MTF1 (metal regulatory transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mtf1 Products(1)

mRNA	Protein	Name
NM_008636.4	NP_032662.3	metal regulatory transcription factor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10952993	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18605988	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9582278	MGI
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	18605988	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA-templated transcription	IDA IDA: Inferred from direct assay	24529376	MGI
acts upstream of cartilage homeostasis	IMP IMP: Inferred from mutant phenotype	24529376	MGI
involved in cellular response to zinc ion	IDA IDA: Inferred from direct assay	24529376	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10952993	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9582278	MGI
acts upstream of or within response to cadmium ion	IMP IMP: Inferred from mutant phenotype	9582278	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	9582278	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24529376	MGI
located in nucleus	IDA IDA: Inferred from direct assay	24529376	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

metal regulatory transcription factor 1

MRE-binding transcription factor	metalloregulatory transcription factor
transcription factor MTF-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08331	MELTF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08765	MTF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08973	MYT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19922	Mtf1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26424	Mtf1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mtf1	NCBI	NCBI:4520

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