Msx2 - msh homeobox 2 Gene

Mus musculus

Also known as Hox8; Hox-8; Hox8.1

Gene ID: 17702 | Gene type: protein coding

About Msx2

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription regulatory region DNA binding activity; negative regulation of transcription, DNA-templated; and osteoblast differentiation. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and regulation of gene expression. Part of transcription regulator complex. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; genitourinary system; jaw; and sensory organ. Used to study craniosynostosis and parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human MSX2 (msh homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Msx2 Products(1)

mRNA	Protein	Name
NM_013601.2	NP_038629.2	homeobox protein MSX-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9265625	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8861098	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	8861098	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20843790	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	8861098	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10451362	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	15383550	MGI
enables transcription factor binding	IDA IDA: Inferred from direct assay	9265625	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	9265625	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	18590716	MGI
acts upstream of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18667074	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within activation of meiosis	IPI IPI: Inferred from physical interaction	22071108	MGI
acts upstream of or within anagen	IMP IMP: Inferred from mutant phenotype	11744114	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within bone morphogenesis	IGI IGI: Inferred from genetic interaction	17693062	MGI
acts upstream of or within bone trabecula formation	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of catagen	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within cell surface receptor signaling pathway involved in heart development	IGI IGI: Inferred from genetic interaction	18667074	MGI
acts upstream of or within cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	8787747	MGI
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	7848824	MGI
acts upstream of or within chondrocyte development	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within embryonic forelimb morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	15930102	MGI
acts upstream of or within embryonic nail plate morphogenesis	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within enamel mineralization	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within endochondral bone growth	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation	IGI IGI: Inferred from genetic interaction	18667074	MGI
acts upstream of or within frontal suture morphogenesis	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within mammary gland epithelium development	IGI IGI: Inferred from genetic interaction	10742104	MGI
acts upstream of mesenchymal cell apoptotic process	IGI IGI: Inferred from genetic interaction	19422820	MGI
acts upstream of or within negative regulation of CREB transcription factor activity	IDA IDA: Inferred from direct assay	15175325	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15383550	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	15175325	MGI
acts upstream of or within negative regulation of keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	19769717	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9265625	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8861098	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17030628	MGI
acts upstream of or within negative regulation of transcription regulatory region DNA binding	IDA IDA: Inferred from direct assay	15175325	MGI
acts upstream of or within odontogenesis	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within osteoblast development	IMP IMP: Inferred from mutant phenotype	10742104	MGI
involved in osteoblast differentiation	IDA IDA: Inferred from direct assay	15383550	MGI
acts upstream of or within outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within outflow tract septum morphogenesis	IGI IGI: Inferred from genetic interaction	17601530	MGI
acts upstream of or within positive regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	18667074	MGI
acts upstream of or within positive regulation of mesenchymal cell apoptotic process	IGI IGI: Inferred from genetic interaction	19422820	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15175325	MGI
acts upstream of or within positive regulation of timing of catagen	IMP IMP: Inferred from mutant phenotype	10742104	MGI
acts upstream of or within regulation of apoptotic process	IDA IDA: Inferred from direct assay	18729207	MGI
acts upstream of or within signal transduction involved in regulation of gene expression	IGI IGI: Inferred from genetic interaction	21465616	MGI
acts upstream of or within stem cell differentiation	IGI IGI: Inferred from genetic interaction	17693062	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	19769717	MGI
acts upstream of or within wound healing, spreading of epidermal cells	IMP IMP: Inferred from mutant phenotype	19769717	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	18285513	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein MSX-2

homeo box, msh-like 2	homeobox protein Hox-8-1
homeobox, msh-like 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08734	MSX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-117184	MSX-2	Antagonist	/	Unkown
HY-RS21379	Msx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27898	Msx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Msx2	NCBI	NCBI:4488

Name
Email *

	Sorry, but the email address you supplied was invalid.