Foxc1 - forkhead box C1 Gene

Mus musculus

Also known as ch; Mf1; Mf4; Fkh1; fkh-1; FREAC3; frkhda

Gene ID: 17300 | Gene type: protein coding

About Foxc1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and vasculature development. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Axenfeld-Rieger syndrome; Axenfeld-Rieger syndrome type 3; anterior segment dysgenesis 3; and glaucoma. Orthologous to human FOXC1 (forkhead box C1). [provided by Alliance of Genome Resources, Apr 2022]

Foxc1 Products(1)

mRNA	Protein	Name
NM_008592.2	NP_032618.2	forkhead box protein C1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	25808752	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18579532	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16678147	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25808752	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	25808752	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25808752	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18579532	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	11562355	MGI
acts upstream of apoptotic process involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within artery morphogenesis	IMP IMP: Inferred from mutant phenotype	10479458	MGI
acts upstream of or within blood vessel development	IGI IGI: Inferred from genetic interaction	16678147	MGI
acts upstream of or within blood vessel diameter maintenance	IGI IGI: Inferred from genetic interaction	16678147	MGI
acts upstream of or within blood vessel remodeling	IGI IGI: Inferred from genetic interaction	11562355	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	4784576	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	10395790	MGI
acts upstream of or within cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	16839542	MGI
involved in cellular response to chemokine	IMP IMP: Inferred from mutant phenotype	18187037	MGI
involved in cerebellum development	IMP IMP: Inferred from mutant phenotype	19668217	MGI
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	18187037	MGI
acts upstream of or within collagen fibril organization	IMP IMP: Inferred from mutant phenotype	10767326	MGI
acts upstream of or within embryonic heart tube development	IGI IGI: Inferred from genetic interaction	16678147	MGI
involved in endochondral ossification	IMP IMP: Inferred from mutant phenotype	25808752	MGI
acts upstream of or within eye development	IMP IMP: Inferred from mutant phenotype	9635428	MGI
acts upstream of or within germ cell migration	IMP IMP: Inferred from mutant phenotype	16412416	MGI
involved in glomerular epithelium development	IMP IMP: Inferred from mutant phenotype	28223138	MGI
acts upstream of or within glycosaminoglycan metabolic process	IMP IMP: Inferred from mutant phenotype	4269479	MGI
acts upstream of or within heart development	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10479458	MGI
acts upstream of or within heart morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	4819561	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	5500588	MGI
acts upstream of or within lacrimal gland development	IMP IMP: Inferred from mutant phenotype	16470615	MGI
acts upstream of or within lymph vessel development	IGI IGI: Inferred from genetic interaction	16678147	MGI
involved in maintenance of lens transparency	IMP IMP: Inferred from mutant phenotype	22171010	MGI
involved in mesenchymal cell development	IDA IDA: Inferred from direct assay	24590069	MGI
acts upstream of or within mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	9635428	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	22171010	MGI
acts upstream of or within negative regulation of apoptotic process involved in outflow tract morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI
involved in negative regulation of lymphangiogenesis	IMP IMP: Inferred from mutant phenotype	22171010	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	28223138	MGI
acts upstream of or within neural crest cell development	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	14512019	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	16412416	MGI
acts upstream of or within paraxial mesoderm formation	IGI IGI: Inferred from genetic interaction	11562355	MGI
involved in paraxial mesoderm formation	IMP IMP: Inferred from mutant phenotype	15196959	MGI
involved in positive regulation of core promoter binding	IMP IMP: Inferred from mutant phenotype	25808752	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	24590069	MGI
involved in positive regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24590069	MGI
involved in positive regulation of hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	24590069	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678147	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18579532	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18187037	MGI
acts upstream of or within regulation of organ growth	IGI IGI: Inferred from genetic interaction	16839542	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	4784576	MGI
involved in somitogenesis	IGI IGI: Inferred from genetic interaction	11562355	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	10704385	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	16678147	MGI
involved in vascular endothelial growth factor signaling pathway	IMP IMP: Inferred from mutant phenotype	22171010	MGI
acts upstream of or within ventricular cardiac muscle tissue morphogenesis	IGI IGI: Inferred from genetic interaction	16839542	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	25808752	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

forkhead box protein C1

FREAC-3	MF-1
congenital hydrocephalus	forkhead-related protein FKHL7
forkhead-related transcription factor 3	mesoderm/mesenchyme forkhead 1
transcription factor FKH-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05041	FOXC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19196	Foxc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25684	Foxc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxc1	NCBI	NCBI:2296

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