2. Gene
  3. Meg3 - maternally expressed 3 Gene

Meg3 - maternally expressed 3 Gene

  • Gene
  • Agent
  • Ortholog
Mus musculus

Also known as Gtl2; D12Bwg1266e; 2900016C05Rik; 3110050O07Rik; 6330408G06Rik

Gene ID: 17263 | Gene type: ncRNA

About Meg3

Summary

This gene is paternally-imprinted and thus expressed predominantly from the maternal allele. It generates alternatively-spliced long non protein-coding RNAs that overlap with the MicroRNAs Mir770 and Mir1906-1. Transcripts from this gene function as negative regulators of growth and may be down-regulated in tumor cells. This gene is expressed in a reciprocal pattern from the nearby Dlk1 (delta-like 1 homolog) gene, which is paternally-expressed. Deletion of this locus disrupts imprinting in this genomic region and results in perinatal morbidity. [provided by RefSeq, Dec 2013]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in chromatin organization IDA
IDA: Inferred from direct assay
26005002 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
19264764 MGI
acts upstream of or within epigenetic programing of female pronucleus IMP
IMP: Inferred from mutant phenotype
20610486 MGI
acts upstream of or within genomic imprinting IDA
IDA: Inferred from direct assay
23195472 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
20610486 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
19264764 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
19264764 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
19264764 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
19264764 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
19264764 MGI
acts upstream of or within skeletal muscle tissue development IMP
IMP: Inferred from mutant phenotype
20610486 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in nucleus IDA
IDA: Inferred from direct assay
27783602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16452 Meg3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16458 MEG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16488 Meg3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Meg3 NCBI NCBI:55384