Ascl1 - achaete-scute family bHLH transcription factor 1 Gene

Mus musculus

Also known as ASH1; Mash1; bHLHa46

Gene ID: 17172 | Gene type: protein coding

About Ascl1

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in nervous system development. Acts upstream of or within several processes, including musculoskeletal movement, spinal reflex action; nervous system development; and neuroendocrine cell differentiation. Located in neuronal cell body and nucleus. Is expressed in several structures, including future brain; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ascl1 Products(1)

mRNA	Protein	Name
NM_008553.5	NP_032579.2	achaete-scute homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17141158	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	23639443	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23639443	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17141158	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within GABAergic neuron differentiation	IGI IGI: Inferred from genetic interaction	15071116	MGI
acts upstream of or within Notch signaling pathway	IGI IGI: Inferred from genetic interaction	15976074	MGI
acts upstream of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	11073877	MGI
acts upstream of or within adrenal chromaffin cell differentiation	IMP IMP: Inferred from mutant phenotype	12361965	MGI
acts upstream of or within carotid body glomus cell differentiation	IMP IMP: Inferred from mutant phenotype	15878769	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	16766700	MGI
acts upstream of or within central nervous system neuron development	IGI IGI: Inferred from genetic interaction	15169849	MGI
acts upstream of or within central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	16469766	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	17678855	MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain	IMP IMP: Inferred from mutant phenotype	22991444	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	23616538	MGI
acts upstream of or within lung neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	9126746	MGI
acts upstream of or within motor neuron migration	IGI IGI: Inferred from genetic interaction	15976074	MGI
acts upstream of or within motor neuron migration	IMP IMP: Inferred from mutant phenotype	15976074	MGI
acts upstream of or within musculoskeletal movement, spinal reflex action	IMP IMP: Inferred from mutant phenotype	23616538	MGI
involved in nervous system development	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	21536733	MGI
acts upstream of or within neuroblast fate determination	IMP IMP: Inferred from mutant phenotype	11032813	MGI
acts upstream of or within neuroblast proliferation	IGI IGI: Inferred from genetic interaction	15976074	MGI
acts upstream of or within neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	10952889	MGI
involved in neuron development	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	9108377	MGI
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	18184563	MGI
involved in neuron differentiation	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	15133515	MGI
involved in neuron fate commitment	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within neuron fate commitment	IGI IGI: Inferred from genetic interaction	16020526	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	12629181	MGI
involved in neuron fate specification	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	16469766	MGI
involved in noradrenergic neuron development	IMP IMP: Inferred from mutant phenotype	18094025	MGI
acts upstream of or within olfactory pit development	IMP IMP: Inferred from mutant phenotype	9108377	MGI
acts upstream of or within oligodendrocyte cell fate commitment	IMP IMP: Inferred from mutant phenotype	17678855	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	18287202	MGI
acts upstream of or within oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	15976074	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	18287202	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	15930101	MGI
acts upstream of or within peripheral nervous system neuron development	IMP IMP: Inferred from mutant phenotype	8845150	MGI
acts upstream of or within positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	11073877	MGI
acts upstream of or within positive regulation of cell cycle	IDA IDA: Inferred from direct assay	21536733	MGI
acts upstream of or within positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	21536733	MGI
acts upstream of or within positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	16469766	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16469766	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17141158	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	8900141	MGI
acts upstream of or within regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	19191219	MGI
acts upstream of or within regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19793887	MGI
acts upstream of or within regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	23284756	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16469766	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18094025	MGI
acts upstream of or within regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22991444	MGI
acts upstream of or within regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	20144606	MGI
acts upstream of or within regulation of timing of subpallium neuron differentiation	IMP IMP: Inferred from mutant phenotype	9876181	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24243019	MGI
acts upstream of or within spinal cord association neuron differentiation	IMP IMP: Inferred from mutant phenotype	16715081	MGI
acts upstream of or within spinal cord oligodendrocyte cell differentiation	IGI IGI: Inferred from genetic interaction	18287202	MGI
acts upstream of or within spinal cord oligodendrocyte cell fate specification	IMP IMP: Inferred from mutant phenotype	18287202	MGI
acts upstream of or within stomach neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	18173746	MGI
acts upstream of or within subpallium neuron fate commitment	IMP IMP: Inferred from mutant phenotype	9876181	MGI
involved in sympathetic ganglion development	IMP IMP: Inferred from mutant phenotype	18094025	MGI
involved in ventral spinal cord interneuron fate commitment	IMP IMP: Inferred from mutant phenotype	16020526	MGI
acts upstream of or within vestibular nucleus development	IMP IMP: Inferred from mutant phenotype	12885554	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	11133151	MGI
located in nucleus	IDA IDA: Inferred from direct assay	1576967	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

achaete-scute homolog 1

achaete-scute complex homolog-like 1	achaete-scute complex-like protein 1
mammalian achaete scute homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01078	ASCL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21486	Ascl1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ascl1	NCBI	NCBI:429

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