2. Gene
  3. Smarca4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Gene

Smarca4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as brg-1

Gene ID: 171379 | Gene type: protein coding

About Smarca4

Summary

Enables chromatin binding activity. Involved in negative regulation of transcription, DNA-templated; nucleosome disassembly; and spermatid development. Located in nucleus. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid Cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Apr 2022]

Smarca4 Products(1)

mRNA Protein Name
NM_134368.1 NP_599195.1 transcription activator BRG1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16452305 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8895581 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
9001244 RGD
Biological Process GO Annotation Evidence Reference Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
9001244 RGD
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12192000 RGD
involved in nucleosome disassembly IDA
IDA: Inferred from direct assay
9001244 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
22215678 RGD
Cellular Component GO Annotation Evidence Reference Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
9001244 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription activator BRG1

ATP-dependent helicase SMARCA4

BAF190A

BRG1-associated factor 190A

SNF2-beta

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

protein brahma homolog 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-144835 Camibirstat Inhibitor 99.06% Phase 1
Pre-clinical Phase
Bioactive Molecules (62)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119374 BRM/BRG1 ATP Inhibitor-1 Inhibitor 99.72% Unkown
HY-145388 AU-15330 99.89% Unkown
HY-128359 ACBI1 99.92% Unkown
HY-163410 AU-24118 Degrader 99.10% Unkown
HY-144896 FHT-1015 Inhibitor 98.41% Unkown
HY-149026 GNE-064 Inhibitor 99.65% Unkown
HY-153361 YD23 98.80% Unkown
HY-125905 VH032-cyclopropane-F 99.92% Unkown
HY-144897 FHT-1204 Inhibitor 99.81% Unkown
HY-149458 FHT-2344 Inhibitor 99.67% Unkown
HY-156568 SMD-3040 Degrader 99.91% Unkown
HY-156568B SMD-3040 formate Degrader 99.78% Unkown
HY-156568A SMD-3040 TFA Degrader 99.90% Unkown
HY-159607 PRT3789 Degrader / Unkown
HY-122573 Bromodomain inhibitor-13 Inhibitor / Unkown
HY-122645 SMARCA2-IN-4 Inhibitor / Unkown
HY-144720 BRG1-IN-1 / Unkown
HY-153425 PROTAC SMARCA2 degrader-2 / Unkown
HY-159449 PROTAC SMARCA2 degrader-5 Degrader / Unkown
HY-159451 PROTAC SMARCA2 degrader-7 Inhibitor / Unkown
HY-159452 PROTAC SMARCA2/4-degrader-1 / Unkown
HY-159453 PROTAC SMARCA2/4-degrader-2 / Unkown
HY-159455 PROTAC SMARCA2/4-degrader-4 Degrader / Unkown
HY-159456 PROTAC SMARCA2/4-degrader-5 Degrader / Unkown
HY-159458 PROTAC SMARCA2/4-degrader-7 / Unkown
HY-159459 PROTAC SMARCA2/4-degrader-32 / Unkown
HY-159460 PROTAC SMARCA2/4-degrader-8 Inhibitor / Unkown
HY-159461 PROTAC SMARCA2/4-degrader-9 Degrader / Unkown
HY-161884 SMARCA2/4-IN-1 Inhibitor / Unkown
HY-161885 SMARCA2-IN-6 Inhibitor / Unkown
HY-161887 SMARCA2-IN-8 Inhibitor / Unkown
HY-162741 PROTAC SMARCA2/4-degrader-33 / Unkown
HY-162743 PROTAC SMARCA2/4-degrader-29 Degrader / Unkown
HY-162744 PROTAC SMARCA2/4-degrader-31 Degrader / Unkown
HY-162748 PROTAC SMARCA2/4-degrader-30 Degrader / Unkown
HY-162815 PROTAC SMARCA2/4-degrader-26 / Unkown
HY-162834 PROTAC SMARCA2/4-degrader-27 Degrader / Unkown
HY-162835 PROTAC SMARCA2/4-degrader-28 Degrader / Unkown
HY-163868 PROTAC SMARCA2/4-degrader-15 Degrader / Unkown
HY-163869 PROTAC SMARCA2/4-degrader-16 / Unkown
HY-163870 PROTAC SMARCA2/4-degrader-17 Degrader / Unkown
HY-163871 PROTAC SMARCA2/4-degrader-18 Degrader / Unkown
HY-163872 PROTAC SMARCA2/4-degrader-10 Degrader / Unkown
HY-163873 PROTAC SMARCA2/4-degrader-20 Degrader / Unkown
HY-163875 PROTAC SMARCA2/4-degrader-22 / Unkown
HY-163876 PROTAC SMARCA2/4-degrader-23 / Unkown
HY-163877 PROTAC SMARCA2/4-degrader-19 Degrader / Unkown
HY-168215 YDR1 Degrader / Unkown
HY-168221 YD54 / Unkown
HY-169270 PROTAC SMARCA2 degrader-19 Degrader / Unkown
HY-169272 PROTAC SMARCA2 degrader-21 Degrader / Unkown
HY-169275 PROTAC SMARCA2 degrader-24 Degrader / Unkown
HY-169278 PROTAC SMARCA2 degrader-26 Degrader / Unkown
HY-169279 PROTAC SMARCA2/4-degrader-34 Degrader / Unkown
HY-170347 PROTAC SMARCA2/4 degrader-36 Degrader / Unkown
HY-170824 SMD-3236 Degrader / Unkown
HY-170828 SMD-1087 Degrader / Unkown
HY-171774 PBRM1/SMARCA2,4-ligand-1 / Unkown
HY-174237 PBRM1/SMARCA2,4 binder-1 / Unkown
HY-RS13405 SMARCA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16803 Smarca4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23244 Smarca4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smarca4 NCBI NCBI:6597