2. Gene
  3. Smad6 - SMAD family member 6 Gene

Smad6 - SMAD family member 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Madh6; b2b390Clo

Gene ID: 17130 | Gene type: protein coding

About Smad6

Summary

Predicted to enable several functions, including SMAD binding activity; signaling receptor binding activity; and transcription regulator inhibitor activity. Involved in heart development; negative regulation of ossification; and positive regulation of pri-miRNA transcription by RNA polymerase II. Acts upstream of or within circulatory system development and ureteric bud development. Predicted to be located in Golgi apparatus; cytosol; and nuclear body. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in aortic valve disease 2; craniosynostosis; and radioulnar synostosis. Orthologous to human SMAD6 (Smad Family member 6). [provided by Alliance of Genome Resources, Apr 2022]

Smad6 Products(1)

mRNA Protein Name
NM_008542.3 NP_032568.3 mothers against decapentaplegic homolog 6
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16601693 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within heart valve development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
10655064 MGI
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
10655064 MGI
involved in outflow tract septum morphogenesis IMP
IMP: Inferred from mutant phenotype
10655064 MGI
involved in positive regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
21145505 MGI
involved in pulmonary valve morphogenesis IMP
IMP: Inferred from mutant phenotype
10655064 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
14656760 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 6

MAD homolog 6

Smad 6

mad homolog 7

mothers against DPP homolog 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13397 SMAD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18407 Smad6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24888 Smad6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad6 NCBI NCBI:4091