2. Gene
  3. Nlgn3 - neuroligin 3 Gene

Nlgn3 - neuroligin 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 171297 | Gene type: protein coding

About Nlgn3

Summary

Enables cell adhesion molecule binding activity; neurexin family protein binding activity; and signaling receptor activity. Involved in several processes, including inhibitory postsynaptic potential; neuron cell-cell adhesion; and synapse assembly. Acts upstream of or within synapse organization. Located in several cellular components, including cell surface; endocytic vesicle; and neuronal cell body. Is integral component of postsynaptic membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of postsynaptic specialization membrane. Colocalizes with dendrite; excitatory synapse; and inhibitory synapse. Used to study autism spectrum disorder. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn3 Products(1)

mRNA Protein Name
NM_134336.2 NP_599163.2 neuroligin-3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cell adhesion molecule binding IPI
IPI: Inferred from physical interaction
15152050 RGD
enables neurexin family protein binding IPI
IPI: Inferred from physical interaction
15152050 RGD
enables signaling receptor activity IDA
IDA: Inferred from direct assay
15797875 RGD
Biological Process GO Annotation Evidence Reference Source
involved in axon extension IMP
IMP: Inferred from mutant phenotype
19406211 RGD
involved in circadian sleep/wake cycle IMP
IMP: Inferred from mutant phenotype
28958035 RGD
involved in inhibitory postsynaptic potential IDA
IDA: Inferred from direct assay
19406211 RGD
involved in neuron cell-cell adhesion IDA
IDA: Inferred from direct assay
15797875 RGD
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
15681343 RGD
involved in positive regulation of inhibitory postsynaptic potential IDA
IDA: Inferred from direct assay
19406211 RGD
involved in positive regulation of protein localization to synapse IMP
IMP: Inferred from mutant phenotype
15681343 RGD
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
15797875 RGD
involved in postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
17897391 RGD
involved in prepulse inhibition IMP
IMP: Inferred from mutant phenotype
28958035 RGD
involved in presynaptic membrane assembly IDA
IDA: Inferred from direct assay
15797875 RGD
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
15797875 RGD
involved in rhythmic synaptic transmission IMP
IMP: Inferred from mutant phenotype
19406211 RGD
involved in synapse assembly IDA
IDA: Inferred from direct assay
15797875 RGD
acts upstream of or within synapse organization IDA
IDA: Inferred from direct assay
15681343 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
17897391 RGD
located in cell surface IDA
IDA: Inferred from direct assay
15797875 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17897391 RGD
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15797875 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
17897391 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17897391 RGD
located in inhibitory synapse IDA
IDA: Inferred from direct assay
17897391 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17897391 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
15797875 RGD
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
17897391 RGD
located in synapse IDA
IDA: Inferred from direct assay
15681343 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroligin-3

gliotactin homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09341 NLGN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18397 Nlgn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24879 Nlgn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nlgn3 NCBI NCBI:54413