Ppp1r15a - protein phosphatase 1, regulatory subunit 15A Gene

Rattus norvegicus

Also known as Peg-3; Gadd34; Myd116; RGD1624209

Gene ID: 171071 | Gene type: protein coding

About Ppp1r15a

Summary

Enables protein Phosphatase 1 binding activity. Involved in several processes, including cellular response to nutrient levels; cellular response to organonitrogen compound; and regulation of cellular protein metabolic process. Located in cytosol. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein Phosphatase 1 regulatory subunit 15A). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r15a Products(1)

mRNA	Protein	Name
NM_133546.3	NP_598230.2	protein phosphatase 1 regulatory subunit 15A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21925170	RGD
enables protein phosphatase 1 binding	IDA IDA: Inferred from direct assay	17760864	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV	IEP IEP: Inferred from expression pattern	9811446	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	21925170	RGD
involved in cellular response to calcium ion starvation	IEP IEP: Inferred from expression pattern	9878749	RGD
involved in cellular response to carbohydrate stimulus	IEP IEP: Inferred from expression pattern	24291486	RGD
involved in cellular response to cordycepin	IEP IEP: Inferred from expression pattern	21597460	RGD
involved in cellular response to desipramine	IEP IEP: Inferred from expression pattern	20549303	RGD
involved in cellular response to gold(3+)	IEP IEP: Inferred from expression pattern	16206274	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	21525936	RGD
involved in cellular response to methamphetamine hydrochloride	IEP IEP: Inferred from expression pattern	22174933	RGD
involved in cellular response to methyl methanesulfonate	IEP IEP: Inferred from expression pattern	9811446	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	9878749	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	23274394	RGD
involved in endoplasmic reticulum unfolded protein response	IEP IEP: Inferred from expression pattern	18266951	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12813455	RGD
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	21925170	RGD
involved in negative regulation of protein processing	IMP IMP: Inferred from mutant phenotype	21925170	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12813455	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16206274	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	15674324	RGD
involved in regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	10611347	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	23644055	RGD
involved in response to endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	11389688	RGD
involved in response to environmental enrichment	IEP IEP: Inferred from expression pattern	23644055	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	23644055	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19564919	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 15A

growth arrest and DNA damage-inducible protein GADD34	myeloid differentiation primary response gene 116
myeloid differentiation primary response protein MyD116 homolog	progression elevated gene 3 protein
protein phosphatase 1, regulatory (inhibitor) s

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-111022	Icerguastat	Inhibitor	99.93%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18956	(E/Z)-Icerguastat	Inhibitor	99.44%	Unkown
HY-110365	Icerguastat Carbonate	Inhibitor	/	Unkown
HY-18956B	(E/Z)-Icerguastat acetate	Inhibitor	/	Unkown
HY-RS10986	PPP1R15A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-18956A	(E/Z)-Icerguastat hydrochloride	Inhibitor	/	Unkown
HY-RS17569	Ppp1r15a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24029	Ppp1r15a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1r15a	NCBI	NCBI:23645

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