Ilk - integrin-linked kinase Gene

Rattus norvegicus

Also known as ILK-1; ILK-2; p59ILK

Gene ID: 170922 | Gene type: protein coding

About Ilk

Summary

Enables SH3 domain binding activity; Integrin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and regulation of protein kinase activity. Located in several cellular components, including costamere; dendritic shaft; and focal adhesion. Part of protein-containing complex. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human ILK (Integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]

Ilk Products(1)

mRNA	Protein	Name
NM_133409.2	NP_596900.1	integrin-linked protein kinase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	18252715	RGD
enables integrin binding	IPI IPI: Inferred from physical interaction	11133699	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	11304546	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	18535176	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17167118	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16170337	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	12629168	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16941698	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16170337	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	12629168	RGD
involved in negative regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	12629168	RGD
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	18535176	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	18535176	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	12629168	RGD
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17182785	RGD
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	16941698	RGD
involved in positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	17490631	RGD
involved in positive regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	17490631	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	16941698	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16941698	RGD
involved in positive regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	18535176	RGD
involved in positive regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	17234816	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	17182785	RGD
involved in positive regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	14550274	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16941698	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	18535176	RGD
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17234816	RGD
involved in regulation of cell growth	IMP IMP: Inferred from mutant phenotype	16170337	RGD
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	16941698	RGD
involved in supramolecular fiber organization	IMP IMP: Inferred from mutant phenotype	17234816	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17490631	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	11133699	RGD
located in costamere	IDA IDA: Inferred from direct assay	16170337	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	17490631	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	11304546	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17490631	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16170337	RGD
located in stress fiber	IDA IDA: Inferred from direct assay	18535176	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	17490631	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

integrin-linked protein kinase

59 kDa serine/threonine-protein kinase

beta-integrin-linked kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18676	OSU-T315		99.88%	Unkown
HY-113439	12-HETE	Inhibitor	95.70%	Unkown
HY-115677	ILK-IN-3	Inhibitor	99.62%	Unkown
HY-18676B	ILK-IN-2		99.41%	Unkown
HY-113439S	12-HETE-d8	Inhibitor	≥98.0%	Unkown
HY-RS06787	ILK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16756	Ilk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23195	Ilk Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ilk	NCBI	NCBI:3611

Name
Email *

	Sorry, but the email address you supplied was invalid.