2. Gene
  3. Mtdh - metadherin Gene

Mtdh - metadherin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Lyric

Gene ID: 170910 | Gene type: protein coding

About Mtdh

Summary

Predicted to enable NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in bicellular tight junction assembly. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and intercellular canaliculus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Apr 2022]

Mtdh Products(1)

mRNA Protein Name
NM_133398.2 NP_596889.1 protein LYRIC
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in bicellular tight junction assembly IEP
IEP: Inferred from expression pattern
15383321 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15383321 RGD
located in bicellular tight junction IDA
IDA: Inferred from direct assay
15383321 RGD
located in intercellular canaliculus IDA
IDA: Inferred from direct assay
15383321 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15383321 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein LYRIC

LYRIC

lysine-rich CEACAM1 co-isolated protein

metastasis adhesion protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-155170 MTDH-SND1 blocker 1 Inhibitor 99.33% Unkown
HY-160801 HKYK-0030 Inhibitor 99.38% Unkown
HY-168850 MTDH-SND1 blocker 2 Inducer / Unkown
HY-RS08762 MTDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18775 Mtdh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25263 Mtdh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mtdh NCBI NCBI:92140