Slc8b1 - solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Gene

Mus musculus

Also known as NCLX; NCKX6; Slc24a6

Gene ID: 170756 | Gene type: protein coding

About Slc8b1

Summary

Enables calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential and protein homodimerization activity. Involved in calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and regulation of lymphocyte chemotaxis. Acts upstream of or within mitochondrial calcium ion transmembrane transport and sodium ion transmembrane transport. Located in mitochondrion and plasma membrane. Is expressed in forelimb bud. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Apr 2022]

Slc8b1 Products(3)

mRNA	Protein	Name
NM_001177594.1	NP_001171065.1	mitochondrial sodium/calcium exchanger protein isoform 2 precursor
NM_001177595.1	NP_001171066.1	mitochondrial sodium/calcium exchanger protein isoform 3 precursor
NM_133221.2	NP_573484.2	mitochondrial sodium/calcium exchanger protein isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium:sodium antiporter activity	IDA IDA: Inferred from direct assay	14625281	MGI
enables calcium:sodium antiporter activity	IMP IMP: Inferred from mutant phenotype	28445457	MGI
enables calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential	IMP IMP: Inferred from mutant phenotype	24067497	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20018762	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium export from the mitochondrion	IMP IMP: Inferred from mutant phenotype	24067497	MGI
acts upstream of or within calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	14625281	MGI
involved in mitochondrial calcium ion homeostasis	IDA IDA: Inferred from direct assay	20018762	MGI
involved in mitochondrial calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	28445457	MGI
acts upstream of or within mitochondrial calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	20018762	MGI
involved in mitochondrial calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	28445457	MGI
involved in regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	20018762	MGI
involved in regulation of lymphocyte chemotaxis	IMP IMP: Inferred from mutant phenotype	27328625	MGI
acts upstream of or within sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	14625281	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	20018762	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14625281	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial sodium/calcium exchanger protein

Na(+)/K(+)/Ca(2+)-exchange protein 6	sodium/calcium exchanger protein, mitochondrial
sodium/potassium/calcium exchanger 6, mitochondrial	solute carrier family 24 (sodium/potassium/calcium exchanger), member 6
solute carrier family 24 member 6	solute

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13340	SLC8B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20598	Slc8b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27106	Slc8b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc8b1	NCBI	NCBI:80024

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