Bco2 - beta-carotene oxygenase 2 Gene

Mus musculus

Also known as CMO2; Bcdo2; Bcmo2; B-diox-II

Gene ID: 170752 | Gene type: protein coding

About Bco2

Summary

Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in isoprenoid metabolic process; regulation of mitochondrial membrane potential; and regulation of Reactive Oxygen Species metabolic process. Acts upstream of or within retinal metabolic process and xanthophyll metabolic process. Located in mitochondrion. Is expressed in brain; embryo; liver; placenta; and yolk sac. Orthologous to human BCO2 (beta-carotene oxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Bco2 Products(2)

mRNA	Protein	Name
NM_001359610.1	NP_001346539.1	carotenoid-cleaving dioxygenase, mitochondrial isoform 2
NM_133217.3	NP_573480.1	carotenoid-cleaving dioxygenase, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta,beta-carotene-9',10'-cleaving oxygenase activity	IDA IDA: Inferred from direct assay	11278918	MGI
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA IDA: Inferred from direct assay	11278918	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in carotene catabolic process	IDA IDA: Inferred from direct assay	11278918	MGI
involved in carotene metabolic process	IDA IDA: Inferred from direct assay	11278918	MGI
involved in carotenoid metabolic process	IMP IMP: Inferred from mutant phenotype	21106934	MGI
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	21106934	MGI
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21106934	MGI
acts upstream of or within retinal metabolic process	IGI IGI: Inferred from genetic interaction	25701869	MGI
involved in xanthophyll catabolic process	IDA IDA: Inferred from direct assay	21106934	MGI
acts upstream of or within xanthophyll metabolic process	IMP IMP: Inferred from mutant phenotype	25701869	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	21106934	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

carotenoid-cleaving dioxygenase, mitochondrial

beta,beta-carotene 9',10'-oxygenase

b,b-carotene-9',10'-dioxygenase	beta-carotene 9', 10'-dioxygenase 2
beta-carotene dioxygenase 2	beta-diox-II

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01447	BCO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21298	Bco2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bco2	NCBI	NCBI:83875

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