Hadha - hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Gene

Rattus norvegicus

Also known as RGD1560655

Gene ID: 170670 | Gene type: protein coding

About Hadha

Summary

Enables several functions, including hydro-lyase activity; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; and nucleotide binding activity. Involved in fatty acid beta-oxidation and response to xenobiotic stimulus. Located in mitochondrion. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hadha Products(1)

mRNA	Protein	Name
NM_130826.2	NP_570839.2	trifunctional enzyme subunit alpha, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-hydroxyacyl-CoA dehydratase activity	IDA IDA: Inferred from direct assay	1730633	RGD
enables 3-hydroxyacyl-CoA dehydrogenase activity	IDA IDA: Inferred from direct assay	1730633	RGD
enables 3-hydroxyacyl-CoA dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	8253773	RGD
enables NAD binding	IDA IDA: Inferred from direct assay	1730633	RGD
enables acetyl-CoA C-acyltransferase activity	IDA IDA: Inferred from direct assay	1730633	RGD
enables enoyl-CoA hydratase activity	IDA IDA: Inferred from direct assay	1730633	RGD
enables enoyl-CoA hydratase activity	IMP IMP: Inferred from mutant phenotype	8253773	RGD
enables fatty-acyl-CoA binding	IDA IDA: Inferred from direct assay	1730633	RGD
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity	IDA IDA: Inferred from direct assay	1730633	RGD
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	20132223	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	1730633	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	12176671	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial fatty acid beta-oxidation multienzyme complex	IDA IDA: Inferred from direct assay	1730633	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

trifunctional enzyme subunit alpha, mitochondrial

TP-alpha	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subun

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0968A	Trimetazidine	Inducer	99.84%	Yes
HY-B0968	Trimetazidine dihydrochloride	Inducer	99.91%	Yes
HY-B0968R	Trimetazidine dihydrochloride (Standard)	Inducer	99.94%	Unkown

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0968S	Trimetazidine-d8 dihydrochloride	Inducer	99.87%	Unkown
HY-RS05990	HADHA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B0968S1	Trimetazidine-d9 dihydrochloride	Inducer	/	Unkown
HY-RS17506	Hadha Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23963	Hadha Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hadha	NCBI	NCBI:3030

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