2. Gene
  3. Fgf21 - fibroblast growth factor 21 Gene

Fgf21 - fibroblast growth factor 21 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Fgf8c

Gene ID: 170580 | Gene type: protein coding

About Fgf21

Summary

Predicted to enable Fibroblast Growth Factor receptor binding activity and growth factor activity. Involved in several processes, including cellular response to glucagon stimulus; endothelial cell apoptotic process; and negative regulation of cell death. Located in extracellular space. Orthologous to human FGF21 (Fibroblast Growth Factor 21). [provided by Alliance of Genome Resources, Apr 2022]

Fgf21 Products(1)

mRNA Protein Name
NM_130752.2 NP_570108.1 fibroblast growth factor 21 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
23262585 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
19660458 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
22166524 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
23118742 RGD
involved in endoplasmic reticulum unfolded protein response IEP
IEP: Inferred from expression pattern
23123503 RGD
involved in endothelial cell apoptotic process IEP
IEP: Inferred from expression pattern
22166524 RGD
involved in negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
22166524 RGD
involved in positive regulation of triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
23262585 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22891896 RGD
involved in response to methionine IEP
IEP: Inferred from expression pattern
23052097 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25133427 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
22166524 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fibroblast growth factor 21

fibroblast growth factor 8c

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99930 Efruxifermin Activator 98.32% Phase 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgf21 NCBI NCBI:26291
Macaca fascicularis Fgf21 NCBI NCBI:102126624
Mus musculus Fgf21 NCBI NCBI:56636