Lrp5 - low density lipoprotein receptor-related protein 5 Gene

Mus musculus

Also known as HBM; LR3; LRP7; OPPG; BMND1; mKIAA4142

Gene ID: 16973 | Gene type: protein coding

About Lrp5

Summary

Enables Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of osteoblast differentiation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including embryonic morphogenesis; mammary gland development; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Used to study exudative vitreoretinopathy and osteoporosis-pseudoglioma syndrome. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; bone remodeling disease (multiple); eye disease (multiple); osteoporosis-pseudoglioma syndrome; and polycystic liver disease. Orthologous to human LRP5 (LDL receptor related protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Lrp5 Products(1)

mRNA	Protein	Name
NM_008513.3	NP_032539.2	low-density lipoprotein receptor-related protein 5 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	11956231	MGI
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	11956231	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18632848	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Norrin signaling pathway	IDA IDA: Inferred from direct assay	15035989	MGI
acts upstream of or within Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22272305	MGI
acts upstream of or within amino acid transport	IMP IMP: Inferred from mutant phenotype	22272305	MGI
acts upstream of or within anatomical structure regression	IMP IMP: Inferred from mutant phenotype	16163358	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	16163358	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	22272305	MGI
involved in bone development	IMP IMP: Inferred from mutant phenotype	17700537	MGI
acts upstream of or within bone remodeling	IGI IGI: Inferred from genetic interaction	15537447	MGI
acts upstream of or within bone remodeling	IMP IMP: Inferred from mutant phenotype	11956231	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	16973609	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	11956231	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	15923619	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16973609	MGI
acts upstream of or within cell migration involved in gastrulation	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	22272305	MGI
acts upstream of or within cell-cell signaling involved in mammary gland development	IMP IMP: Inferred from mutant phenotype	16973609	MGI
acts upstream of or within cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	12509515	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within establishment of blood-brain barrier	IMP IMP: Inferred from mutant phenotype	25083995	MGI
acts upstream of or within establishment of blood-retinal barrier	IMP IMP: Inferred from mutant phenotype	25083995	MGI
involved in extracellular matrix-cell signaling	IDA IDA: Inferred from direct assay	15035989	MGI
acts upstream of or within gastrulation with mouth forming second	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	22272305	MGI
acts upstream of or within limb morphogenesis	IGI IGI: Inferred from genetic interaction	15537447	MGI
acts upstream of or within mammary gland duct morphogenesis	IGI IGI: Inferred from genetic interaction	19503830	MGI
acts upstream of or within mesodermal cell migration	IGI IGI: Inferred from genetic interaction	15142971	MGI
acts upstream of or within osteoblast development	IMP IMP: Inferred from mutant phenotype	16790443	MGI
involved in osteoblast development	IMP IMP: Inferred from mutant phenotype	17700537	MGI
acts upstream of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	11956231	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15035989	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15035989	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	26891291	MGI
acts upstream of or within positive regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	11956231	MGI
NOT involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	18957220	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11956231	MGI
acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	12509515	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	22272305	MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye	IGI IGI: Inferred from genetic interaction	19837032	MGI
acts upstream of or within retina vasculature morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	11956231	MGI
involved in retinal blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	27031698	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19672307	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	16163358	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

low-density lipoprotein receptor-related protein 5

LRP-5	LRP-7
low-density lipoprotein receptor-related protein 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125146	BMD4503-2		99.21%	Unkown
HY-RS16292	Lrp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-E70390	C1s Enzyme	Antagonist	/	Unkown
HY-RS07800	LRP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-169508	BMD4503-1	Modulator	/	Unkown
HY-RS24282	Lrp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991569	PF-04840082	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrp5	NCBI	NCBI:4041

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