2. Gene
  3. Loxl1 - lysyl oxidase-like 1 Gene

Loxl1 - lysyl oxidase-like 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Loxl

Gene ID: 16949 | Gene type: protein coding

About Loxl1

Summary

This gene encodes a member of the Lysyl Oxidase family of copper-dependent Enzymes that catalyze the formation of lysine-derived crosslinks in proteins such as Collagen and elastin. The encoded preproprotein undergoes proteolytic processing to generate the mature, functional enzyme. Mice lacking the encoded protein fail to deposit normal elastic fibers in the uterine tract post partum and develop pelvic organ prolapse, enlarged airspaces of the lung, loose skin and vascular abnormalities with concomitant tropoelastin accumulation. [provided by RefSeq, Sep 2016]

Loxl1 Products(1)

mRNA Protein Name
NM_010729.3 NP_034859.2 lysyl oxidase homolog 1 preproprotein
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IDA
IDA: Inferred from direct assay
15482472 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14745449 MGI
enables protein-lysine 6-oxidase activity IDA
IDA: Inferred from direct assay
14745449 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
10022501 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
14745449 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lysyl oxidase homolog 1

lysyl oxidase 2

lysyl oxidase-like protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-151499A PXS-6302 hydrochloride Inhibitor 99.83% Unkown
HY-151498A PXS-4787 hydrochloride Inhibitor 99.71% Unkown
HY-151498 PXS-4787 Inhibitor / Unkown
HY-151499 PXS-6302 Inhibitor / Unkown
HY-RS07741 LOXL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19707 Loxl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26203 Loxl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Loxl1 NCBI NCBI:4016