Sh2b3 - SH2B adaptor protein 3 Gene

Mus musculus

Also known as Lnk

Gene ID: 16923 | Gene type: protein coding

About Sh2b3

Summary

This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and Apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Sh2b3 Products(4)

mRNA	Protein	Name
NM_001306126.2	NP_001293055.1	SH2B adapter protein 3 isoform 1
NM_001306127.2	NP_001293056.1	SH2B adapter protein 3 isoform 1
NM_001306128.2	NP_001293057.1	SH2B adapter protein 3 isoform 2
NM_008507.5	NP_032533.1	SH2B adapter protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11805142	MGI
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	14612394	MGI
enables signaling receptor complex adaptor activity	IPI IPI: Inferred from physical interaction	14612394	MGI
enables stem cell factor receptor binding	IDA IDA: Inferred from direct assay	14612394	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative effect cellular response to chemokine	IMP IMP: Inferred from mutant phenotype	15337790	MGI
involved in cellular response to interleukin-3	IDA IDA: Inferred from direct assay	15337790	MGI
acts upstream of or within embryonic hemopoiesis	IDA IDA: Inferred from direct assay	14612394	MGI
acts upstream of negative effect embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	14612394	MGI
acts upstream of or within embryonic hemopoiesis	IMP IMP: Inferred from mutant phenotype	14612394	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	14612394	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	11805142	MGI
acts upstream of or within intracellular signal transduction	IDA IDA: Inferred from direct assay	11805142	MGI
involved in megakaryocyte development	IMP IMP: Inferred from mutant phenotype	15337790	MGI
involved in monocyte homeostasis	IGI IGI: Inferred from genetic interaction	27430239	MGI
involved in negative regulation of Kit signaling pathway	IMP IMP: Inferred from mutant phenotype	14612394	MGI
involved in negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15337790	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15337790	MGI
involved in negative regulation of chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15337790	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	15337790	MGI
involved in negative regulation of platelet aggregation	IGI IGI: Inferred from genetic interaction	27430239	MGI
involved in negative regulation of receptor signaling pathway via STAT	IMP IMP: Inferred from mutant phenotype	15337790	MGI
involved in neutrophil homeostasis	IGI IGI: Inferred from genetic interaction	27430239	MGI
acts upstream of negative effect thrombopoietin-mediated signaling pathway	IGI IGI: Inferred from genetic interaction	27430239	MGI
involved in thrombopoietin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	15337790	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SH2B adapter protein 3

linker of T-cell receptor pathways	lymphocyte-specific adapter protein Lnk
signal transduction protein Lnk

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12820	SH2B3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22804	Sh2b3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sh2b3	NCBI	NCBI:10019

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