2. Gene
  3. Lmnb1 - lamin B1 Gene

Lmnb1 - lamin B1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 16906 | Gene type: protein coding

About Lmnb1

Summary

Enables Phospholipase binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in cellular response to monosodium L-glutamate. Located in nuclear inner membrane and nuclear lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Used to study adult-onset autosomal dominant demyelinating leukodystrophy. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Apr 2022]

Lmnb1 Products(1)

mRNA Protein Name
NM_010721.2 NP_034851.2 lamin-B1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
29484800 MGI
enables phospholipase binding IPI
IPI: Inferred from physical interaction
19028838 MGI
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
23117660 MGI
enables structural constituent of nuclear lamina IDA
IDA: Inferred from direct assay
28241138 MGI
Cellular Component GO Annotation Evidence Reference Source
located in lamin filament IDA
IDA: Inferred from direct assay
8032679 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
16364897 MGI
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
25123547 MGI
is active in nuclear lamina IDA
IDA: Inferred from direct assay
28241138 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
20153721 MGI
located in nuclear periphery IDA
IDA: Inferred from direct assay
28811369 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
19028838 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12714744 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lamin-B1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07715 LMNB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19706 Lmnb1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26202 Lmnb1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lmnb1 NCBI NCBI:4001