2. Gene
  3. Lipe - lipase, hormone sensitive Gene

Lipe - lipase, hormone sensitive Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HSL; REH; 4933403G17Rik

Gene ID: 16890 | Gene type: protein coding

About Lipe

Summary

Enables carboxylic ester hydrolase activity; protein kinase binding activity; and serine hydrolase activity. Involved in ether lipid metabolic process and lipid catabolic process. Acts upstream of or within cellular lipid catabolic process and cellular response to cold. Located in cytosol; lipid droplet; and membrane. Is expressed in adipose tissue; ileum; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (Lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Apr 2022]

Lipe Products(2)

mRNA Protein Name
NM_001039507.2 NP_001034596.1 hormone-sensitive lipase isoform 2
NM_010719.5 NP_034849.2 hormone-sensitive lipase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables diacylglycerol lipase activity IDA
IDA: Inferred from direct assay
23066022 MGI
enables monoacylglycerol lipase activity IDA
IDA: Inferred from direct assay
21454566 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19717842 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15878856 MGI
enables retinyl-palmitate esterase activity IDA
IDA: Inferred from direct assay
15550674 MGI
enables serine hydrolase activity IDA
IDA: Inferred from direct assay
16818490 MGI
enables sterol ester esterase activity IDA
IDA: Inferred from direct assay
15550674 MGI
enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
15550674 MGI
enables triacylglycerol lipase activity IMP
IMP: Inferred from mutant phenotype
17074755 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to cold IDA
IDA: Inferred from direct assay
30862682 MGI
acts upstream of or within diacylglycerol catabolic process IDA
IDA: Inferred from direct assay
16804080 MGI
involved in diacylglycerol catabolic process IDA
IDA: Inferred from direct assay
23066022 MGI
acts upstream of or within diacylglycerol catabolic process IMP
IMP: Inferred from mutant phenotype
11717312 MGI
involved in ether lipid metabolic process IDA
IDA: Inferred from direct assay
20625037 MGI
involved in lipid catabolic process IDA
IDA: Inferred from direct assay
15878856 MGI
acts upstream of or within long-chain fatty acid catabolic process IDA
IDA: Inferred from direct assay
16804080 MGI
acts upstream of or within triglyceride catabolic process IDA
IDA: Inferred from direct assay
16804080 MGI
acts upstream of or within triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
11717312 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
15550674 MGI
located in lipid droplet IDA
IDA: Inferred from direct assay
15878856 MGI
located in membrane IDA
IDA: Inferred from direct assay
15550674 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hormone-sensitive lipase

monoacylglycerol lipase LIPE

retinyl ester hydrolase

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112083 BAY-3827 Inhibitor 99.66% Unkown
HY-144734 Pantothenate kinase-IN-1 Inhibitor / Unkown
HY-RS07687 LIPE Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18621 Lipe Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25107 Lipe Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lipe NCBI NCBI:3991