Lhx1 - LIM homeobox protein 1 Gene

Mus musculus

Also known as Lim1

Gene ID: 16869 | Gene type: protein coding

About Lhx1

Summary

Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; generation of neurons; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; gastrulation; and regionalization. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesoderm; genitourinary system; gut; and sensory organ. Orthologous to human LHX1 (LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Lhx1 Products(1)

mRNA	Protein	Name
NM_008498.3	NP_032524.1	LIM/homeobox protein Lhx1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	17166926	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	11291865	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	26494787	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9468533	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in S-shaped body morphogenesis	IMP IMP: Inferred from mutant phenotype	17610272	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	15930111	MGI
acts upstream of or within anatomical structure morphogenesis	IMP IMP: Inferred from mutant phenotype	10328927	MGI
acts upstream of or within anterior/posterior axis specification	IGI IGI: Inferred from genetic interaction	10529425	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	10498685	MGI
involved in branching involved in ureteric bud morphogenesis	IEP IEP: Inferred from expression pattern	7909549	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	26494787	MGI
acts upstream of or within cell-cell signaling	IGI IGI: Inferred from genetic interaction	17664423	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IGI IGI: Inferred from genetic interaction	17664423	MGI
acts upstream of or within cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation	IGI IGI: Inferred from genetic interaction	17664423	MGI
acts upstream of or within cerebellum development	IGI IGI: Inferred from genetic interaction	17664423	MGI
involved in cervix development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in comma-shaped body morphogenesis	IMP IMP: Inferred from mutant phenotype	17610272	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within ectoderm formation	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within embryonic pattern specification	IGI IGI: Inferred from genetic interaction	10529425	MGI
involved in embryonic retina morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	18094249	MGI
involved in embryonic viscerocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	14695376	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	26494787	MGI
acts upstream of or within endoderm formation	IMP IMP: Inferred from mutant phenotype	15355796	MGI
involved in epithelium development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
acts upstream of or within forebrain regionalization	IGI IGI: Inferred from genetic interaction	10529425	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	15355796	MGI
acts upstream of or within head development	IGI IGI: Inferred from genetic interaction	10529425	MGI
involved in head development	IGI IGI: Inferred from genetic interaction	15857913	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	15930111	MGI
involved in lateral motor column neuron migration	IMP IMP: Inferred from mutant phenotype	20711475	MGI
acts upstream of mesendoderm development	IMP IMP: Inferred from mutant phenotype	26494787	MGI
involved in mesonephros development	IEP IEP: Inferred from expression pattern	7909549	MGI
involved in metanephric S-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	7909549	MGI
involved in metanephric renal vesicle morphogenesis	IEP IEP: Inferred from expression pattern	7909549	MGI
involved in metanephros development	IEP IEP: Inferred from expression pattern	7909549	MGI
involved in motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	20711475	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17610272	MGI
involved in nephric duct elongation	IMP IMP: Inferred from mutant phenotype	16216236	MGI
involved in nephric duct morphogenesis	IMP IMP: Inferred from mutant phenotype	16216236	MGI
involved in oviduct development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in oviduct epithelium development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in paramesonephric duct development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	10498685	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	15930111	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	17166926	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in positive regulation of anterior head development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16216236	MGI
involved in positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in positive regulation of gastrulation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in positive regulation of nephron tubule epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	16216236	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	17664423	MGI
acts upstream of or within primitive streak formation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in primitive streak formation	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in pronephros development	IEP IEP: Inferred from expression pattern	7909549	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	10328927	MGI
involved in renal vesicle morphogenesis	IMP IMP: Inferred from mutant phenotype	17610272	MGI
involved in retina development in camera-type eye	IEP IEP: Inferred from expression pattern	10741426	MGI
involved in retina layer formation	IEP IEP: Inferred from expression pattern	10741426	MGI
involved in retina layer formation	IMP IMP: Inferred from mutant phenotype	18094249	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	11291865	MGI
involved in spinal cord association neuron differentiation	IGI IGI: Inferred from genetic interaction	17166926	MGI
involved in spinal cord development	IEP IEP: Inferred from expression pattern	7909549	MGI
involved in telencephalon development	IEP IEP: Inferred from expression pattern	7909549	MGI
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15857913	MGI
acts upstream of or within ureter morphogenesis	IGI IGI: Inferred from genetic interaction	21731775	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	15930111	MGI
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	15930111	MGI
involved in uterine epithelium development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in uterus development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in vagina development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in ventral spinal cord development	IEP IEP: Inferred from expression pattern	20711475	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	10482234	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8793615	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	15857913	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	26494787	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

LIM/homeobox protein Lhx1

LIM homeo box protein 1

homeobox protein Lim-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07631	LHX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21365	Lhx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lhx1	NCBI	NCBI:3975

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